Expression of NAALAD2 in cancer - Summary

CANCER ATLAS

Gene description

N-acetylated alpha-linked acidic dipeptidase 2

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA060820	HPA065419

GENE INFORMATION
Gene name	NAALAD2 (HGNC Symbol)
Synonyms	GPCIII, NAADALASE2, NAALADASE2
Description	N-acetylated alpha-linked acidic dipeptidase 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Chromosome	11
Cytoband	q14.3
Chromosome location (bp)	90131515 - 90192894
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000077616 (version 83.38)
Entrez gene	10003
UniProt	Q9Y3Q0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3Q0
Antibodypedia	NAALAD2 antibodies

PROTEIN BROWSER

NAALAD2-001	NAALAD2-002	NAALAD2-006	NAALAD2-007	NAALAD2-008	NAALAD2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAALAD2-001 ENSP00000432481 ENST00000534061	Q9Y3Q0 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008239 [dipeptidyl-peptidase activity] GO:0008652 [cellular amino acid biosynthetic process] GO:0016021 [integral component of membrane] GO:0016805 [dipeptidase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042135 [neurotransmitter catabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050129 [N-formylglutamate deformylase activity] Show all	740 aa 83.6 kDa	No	1
NAALAD2-002 ENSP00000320083 ENST00000321955	J3KNJ3 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	707 aa 80.2 kDa	No	1
NAALAD2-006 ENSP00000435249 ENST00000525171	E9PKX5 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	372 aa 42.2 kDa	No	1
NAALAD2-007 ENSP00000431989 ENST00000525497	E9PII2 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	88 aa 10.2 kDa	No	1
NAALAD2-008 ENSP00000435670 ENST00000526637	E9PJ53 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 12.2 kDa	No	0
NAALAD2-009 ENSP00000365111 ENST00000375944	Q9Y3Q0 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008239 [dipeptidyl-peptidase activity] GO:0008652 [cellular amino acid biosynthetic process] GO:0016021 [integral component of membrane] GO:0016805 [dipeptidase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	305 aa 34.4 kDa	No	1