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UBE2K

GENERAL INFORMATION

Gene name

 UBE2K

Gene description

 Ubiquitin-conjugating enzyme E2K

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA028869 , CAB033212 , CAB033515
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBE2K (HGNC Symbol)

Synonyms

 HIP2, HYPG, UBC1

Description

 Ubiquitin-conjugating enzyme E2K (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 39698044 - 39782792

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078140 (version 83.38)

Entrez gene

 3093

UniProt

 P61086 (UniProt - Evidence at protein level)

neXtProt

 NX_P61086

Antibodypedia

 UBE2K antibodies

PROTEIN BROWSER
UBE2K-001
UBE2K-004
UBE2K-005
UBE2K-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2K-001
ENSP00000261427
ENST00000261427
P61086 [Direct mapping]
Ubiquitin-conjugating enzyme E2 K
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010994 [free ubiquitin chain polymerization]
GO:0015629 [actin cytoskeleton]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032433 [filopodium tip]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0035458 [cellular response to interferon-beta]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 200 aa
22.4 kDa 		No 0
UBE2K-004
ENSP00000425301
ENST00000510934
D6RDM7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 K
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
Show all
 123 aa
14 kDa 		No 0
UBE2K-005
ENSP00000421203
ENST00000503368
P61086 [Direct mapping]
Ubiquitin-conjugating enzyme E2 K
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010994 [free ubiquitin chain polymerization]
GO:0015629 [actin cytoskeleton]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0035458 [cellular response to interferon-beta]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 149 aa
16.6 kDa 		No 0
UBE2K-006
ENSP00000390483
ENST00000445950
P61086 [Direct mapping]
Ubiquitin-conjugating enzyme E2 K
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010994 [free ubiquitin chain polymerization]
GO:0015629 [actin cytoskeleton]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0035458 [cellular response to interferon-beta]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 157 aa
17.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.