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TULP3

CANCER ATLAS

Gene description

 Tubby like protein 3

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015285

GENE INFORMATION

Gene name

 TULP3 (HGNC Symbol)

Synonyms

 TUBL3

Description

 Tubby like protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 2877223 - 2941140

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078246 (version 83.38)

Entrez gene

 7289

UniProt

 O75386 (UniProt - Evidence at protein level)

neXtProt

 NX_O75386

Antibodypedia

 TULP3 antibodies

PROTEIN BROWSER
TULP3-001
TULP3-004
TULP3-005
TULP3-007
TULP3-008
TULP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TULP3-001
ENSP00000410051
ENST00000448120
O75386 [Direct mapping]
Tubby-related protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0019899 [enzyme binding]
GO:0030991 [intraciliary transport particle A]
GO:0032403 [protein complex binding]
GO:0035091 [phosphatidylinositol binding]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0072372 [primary cilium]
GO:0097500 [receptor localization to nonmotile primary cilium]
GO:0097546 [ciliary base]
GO:1903546 [protein localization to photoreceptor outer segment]
Show all
 442 aa
49.6 kDa 		No 0
TULP3-004
ENSP00000380321
ENST00000397132
O75386 [Direct mapping]
Tubby-related protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001841 [neural tube formation]
GO:0001843 [neural tube closure]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007420 [brain development]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009952 [anterior/posterior pattern specification]
GO:0019899 [enzyme binding]
GO:0021904 [dorsal/ventral neural tube patterning]
GO:0021914 [negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning]
GO:0021915 [neural tube development]
GO:0021953 [central nervous system neuron differentiation]
GO:0030991 [intraciliary transport particle A]
GO:0031076 [embryonic camera-type eye development]
GO:0032403 [protein complex binding]
GO:0035091 [phosphatidylinositol binding]
GO:0042733 [embryonic digit morphogenesis]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0048702 [embryonic neurocranium morphogenesis]
GO:0060173 [limb development]
GO:0060348 [bone development]
GO:0060434 [bronchus morphogenesis]
GO:0060831 [smoothened signaling pathway involved in dorsal/ventral neural tube patterning]
GO:0061548 [ganglion development]
GO:0072372 [primary cilium]
GO:0097500 [receptor localization to nonmotile primary cilium]
GO:0097546 [ciliary base]
GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning]
GO:1903546 [protein localization to photoreceptor outer segment]
Show all
 501 aa
56.5 kDa 		No 0
TULP3-005
ENSP00000442631
ENST00000544943
F5H7B9 [Direct mapping]
Tubby-related protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 137 aa
15.6 kDa 		No 0
TULP3-007
ENSP00000440364
ENST00000538704
H0YFU8 [Direct mapping]
Tubby-related protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 109 aa
12.4 kDa 		No 0
TULP3-008
ENSP00000441319
ENST00000541678
H0YG12 [Direct mapping]
Tubby-related protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 133 aa
15.1 kDa 		No 0
TULP3-201
ENSP00000482208
ENST00000610453
A0A087WYY4 [Direct mapping]
Tubby-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 440 aa
49.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.