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HOXA9

GENERAL INFORMATION

Gene name

 HOXA9

Gene description

 Homeobox A9

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (fallopian tube)
FANTOM5:Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA061982
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)

GENE INFORMATION

Gene name

 HOXA9 (HGNC Symbol)

Synonyms

 HOX1, HOX1G

Description

 Homeobox A9 (HGNC Symbol)

Entrez gene summary

 In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]

Chromosome

 7

Cytoband

 p15.2

Chromosome location (bp)

 27162435 - 27175180

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078399 (version 83.38)

Entrez gene

 3205

UniProt

 P31269 (UniProt - Evidence at protein level)

neXtProt

 NX_P31269

Antibodypedia

 HOXA9 antibodies

PROTEIN BROWSER
HOXA9-001
HOXA9-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXA9-001
ENSP00000343619
ENST00000343483
P31269 [Direct mapping]
Homeobox protein Hox-A9
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0008584 [male gonad development]
GO:0009952 [anterior/posterior pattern specification]
GO:0009954 [proximal/distal pattern formation]
GO:0010468 [regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0030879 [mammary gland development]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0042118 [endothelial cell activation]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0048706 [embryonic skeletal system development]
GO:0060065 [uterus development]
GO:0060216 [definitive hemopoiesis]
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 272 aa
30.2 kDa 		No 0
HOXA9-003
ENSP00000379634
ENST00000396345
A8MVF3 [Direct mapping]
Homeobox protein Hox-A9
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
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 106 aa
10.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.