Cell atlas - MLLT10 - The Human Protein Atlas

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MLLT10

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MLLT10
Gene description	Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA005747
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005747	A-431	Nucleoplasm
	HPA005747	U-2 OS	Nucleoplasm
	HPA005747	U-251 MG	Nucleoplasm
	HPA005747	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MLLT10 (HGNC Symbol)
Synonyms	AF10
Description	Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Chromosome	10
Cytoband	p12.31
Chromosome location (bp)	21524675 - 21743630
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078403 (version 83.38)
Entrez gene	8028
UniProt	P55197 (UniProt - Evidence at protein level)
neXtProt	NX_P55197
Antibodypedia	MLLT10 antibodies

PROTEIN BROWSER

MLLT10-001	MLLT10-002	MLLT10-003	MLLT10-004	MLLT10-007	MLLT10-009	MLLT10-013	MLLT10-015	MLLT10-201	MLLT10-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MLLT10-001 ENSP00000366272 ENST00000377072	P55197 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	1027 aa 109 kDa	No	0
MLLT10-002 ENSP00000307411 ENST00000307729	P55197 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	1068 aa 113.3 kDa	No	0
MLLT10-003 ENSP00000366295 ENST00000377091	P55197 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	126 aa 13.9 kDa	No	0
MLLT10-004 ENSP00000397800 ENST00000430455	H0Y5C4 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	62 aa 6.9 kDa	No	0
MLLT10-007 ENSP00000408281 ENST00000438473	Q5JT35 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		361 aa 37.4 kDa	No	0
MLLT10-009 ENSP00000399883 ENST00000420525	H0Y5P4 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		180 aa 18.3 kDa	No	0
MLLT10-013 ENSP00000366304 ENST00000377100	P55197 [Direct mapping] Protein AF-10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	179 aa 20 kDa	No	1
MLLT10-015 ENSP00000488569 ENST00000631589	P55197 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	1068 aa 113.3 kDa	No	0
MLLT10-201 ENSP00000366258 ENST00000377059	P55197 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	1068 aa 113.3 kDa	No	0
MLLT10-202 ENSP00000484335 ENST00000621220	P55197 [Direct mapping] Protein AF-10 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	126 aa 13.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.