Expression of ADCYAP1R1 in cancer - Summary

CANCER ATLAS

Gene description

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

Protein class

G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049877

GENE INFORMATION
Gene name	ADCYAP1R1 (HGNC Symbol)
Synonyms	PAC1, PAC1R, PACAPR
Description	Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (HGNC Symbol)
Entrez gene summary	This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	31052461 - 31111479
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078549 (version 83.38)
Entrez gene	117
UniProt	P41586 (UniProt - Evidence at protein level)
neXtProt	NX_P41586
Antibodypedia	ADCYAP1R1 antibodies

PROTEIN BROWSER

ADCYAP1R1-001	ADCYAP1R1-002	ADCYAP1R1-003	ADCYAP1R1-004	ADCYAP1R1-005	ADCYAP1R1-006	ADCYAP1R1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADCYAP1R1-001 ENSP00000306620 ENST00000304166	P41586 [Direct mapping] Pituitary adenylate cyclase-activating polypeptide type I receptor A0A090N8F8 [Target identity:100%; Query identity:100%] Adenylate cyclase activating polypeptide 1 (Pituitary) receptor type I Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007283 [spermatogenesis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0043235 [receptor complex] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	468 aa 53.3 kDa	Yes	7
ADCYAP1R1-002 ENSP00000387335 ENST00000409363	P41586 [Direct mapping] Pituitary adenylate cyclase-activating polypeptide type I receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007283 [spermatogenesis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0043235 [receptor complex] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	447 aa 51 kDa	Yes	7
ADCYAP1R1-003 ENSP00000379514 ENST00000396211	P41586 [Direct mapping] Pituitary adenylate cyclase-activating polypeptide type I receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007283 [spermatogenesis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0043235 [receptor complex] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	496 aa 56.5 kDa	Yes	7
ADCYAP1R1-004 ENSP00000386395 ENST00000409489	E9PFU5 [Direct mapping] Pituitary adenylate cyclase-activating polypeptide type I receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	524 aa 59.6 kDa	Yes	7
ADCYAP1R1-005 ENSP00000416622 ENST00000436116	H0Y813 [Direct mapping] Pituitary adenylate cyclase-activating polypeptide type I receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	148 aa 16.5 kDa	No	3
ADCYAP1R1-006 ENSP00000400893 ENST00000431811	C9JVH3 [Direct mapping] Pituitary adenylate cyclase-activating polypeptide type I receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] Show all	74 aa 8.1 kDa	Yes	0
ADCYAP1R1-201 ENSP00000483721 ENST00000614107	P41586 [Direct mapping] Pituitary adenylate cyclase-activating polypeptide type I receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005791 [rough endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005901 [caveola] GO:0005923 [bicellular tight junction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007202 [activation of phospholipase C activity] GO:0007283 [spermatogenesis] GO:0008179 [adenylate cyclase binding] GO:0009986 [cell surface] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019933 [cAMP-mediated signaling] GO:0030154 [cell differentiation] GO:0030306 [ADP-ribosylation factor binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0032355 [response to estradiol] GO:0033555 [multicellular organismal response to stress] GO:0042493 [response to drug] GO:0042923 [neuropeptide binding] GO:0043005 [neuron projection] GO:0043235 [receptor complex] GO:0045471 [response to ethanol] GO:0046545 [development of primary female sexual characteristics] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0060548 [negative regulation of cell death] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] Show all	496 aa 56.5 kDa	Yes	7