Expression of PCM1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Pericentriolar material 1

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA023370	HPA023374	CAB058695

GENE INFORMATION
Gene name	PCM1 (HGNC Symbol)
Synonyms	PTC4
Description	Pericentriolar material 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	17922840 - 18029944
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078674 (version 83.38)
Entrez gene	5108
UniProt	Q15154 (UniProt - Evidence at protein level)
neXtProt	NX_Q15154
Antibodypedia	PCM1 antibodies

PROTEIN BROWSER

PCM1-001	PCM1-002	PCM1-003	PCM1-004	PCM1-005	PCM1-007	PCM1-016	PCM1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCM1-001 ENSP00000327077 ENST00000325083	Q15154 [Direct mapping] Pericentriolar material 1 protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000242 [pericentriolar material] GO:0000278 [mitotic cell cycle] GO:0001764 [neuron migration] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0016020 [membrane] GO:0022027 [interkinetic nuclear migration] GO:0031122 [cytoplasmic microtubule organization] GO:0031965 [nuclear membrane] GO:0034451 [centriolar satellite] GO:0034453 [microtubule anchoring] GO:0034454 [microtubule anchoring at centrosome] GO:0035058 [nonmotile primary cilium assembly] GO:0035735 [intraciliary transport involved in cilium morphogenesis] GO:0036064 [ciliary basal body] GO:0042384 [cilium assembly] GO:0042802 [identical protein binding] GO:0043234 [protein complex] GO:0050768 [negative regulation of neurogenesis] GO:0051297 [centrosome organization] GO:0071539 [protein localization to centrosome] GO:0090316 [positive regulation of intracellular protein transport] GO:0097150 [neuronal stem cell population maintenance] Show all	2024 aa 228.6 kDa	No	0
PCM1-002 ENSP00000428131 ENST00000517730	E7EV93 [Direct mapping] Pericentriolar material 1 protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0031965 [nuclear membrane] Show all	749 aa 84.1 kDa	No	0
PCM1-003 ENSP00000431099 ENST00000519253	E7ETA6 [Direct mapping] Pericentriolar material 1 protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0031965 [nuclear membrane] Show all	2016 aa 227.7 kDa	No	0
PCM1-004 ENSP00000430521 ENST00000524226	A6NNN6 [Direct mapping] Pericentriolar material 1 protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0031965 [nuclear membrane] Show all	1860 aa 210.1 kDa	No	0
PCM1-005 ENSP00000428123 ENST00000518537	E9PGW9 [Direct mapping] Pericentriolar material 1 protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		530 aa 59.2 kDa	No	0
PCM1-007 ENSP00000429941 ENST00000523055	E5RGQ4 [Direct mapping] Pericentriolar material 1 protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		408 aa 46.3 kDa	No	0
PCM1-016 ENSP00000429054 ENST00000522275	H0YBA1 [Direct mapping] Pericentriolar material 1 protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		764 aa 85.7 kDa	No	0
PCM1-201 ENSP00000328332 ENST00000327578	A6NNN6 [Direct mapping] Pericentriolar material 1 protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0031965 [nuclear membrane] Show all	1860 aa 210.1 kDa	No	0