Cell atlas - CBFA2T2 - The Human Protein Atlas

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CBFA2T2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CBFA2T2
Gene description	Core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA072433
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072433	SH-SY5Y	Nuclear speckles
	HPA072433	SiHa	Nuclear speckles
	HPA072433	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	CBFA2T2 (HGNC Symbol)
Synonyms	MTGR1, ZMYND3
Description	Core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (HGNC Symbol)
Entrez gene summary	In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband
Chromosome location (bp)	33490075 - 33650036
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078699 (version 83.38)
Entrez gene	9139
UniProt	O43439 (UniProt - Evidence at protein level)
neXtProt	NX_O43439
Antibodypedia	CBFA2T2 antibodies

PROTEIN BROWSER

CBFA2T2-003	CBFA2T2-004	CBFA2T2-005	CBFA2T2-007	CBFA2T2-009	CBFA2T2-201	CBFA2T2-202	CBFA2T2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CBFA2T2-003 ENSP00000364428 ENST00000375279	O43439 [Direct mapping] Protein CBFA2T2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	604 aa 67.1 kDa	No	0
CBFA2T2-004 ENSP00000433270 ENST00000492345	O43439 [Direct mapping] Protein CBFA2T2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	575 aa 63.9 kDa	No	0
CBFA2T2-005 ENSP00000341865 ENST00000344201	O43439 [Direct mapping] Protein CBFA2T2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	263 aa 28.6 kDa	No	0
CBFA2T2-007 ENSP00000352622 ENST00000359606	O43439 [Direct mapping] Protein CBFA2T2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	614 aa 68 kDa	No	0
CBFA2T2-009 ENSP00000345810 ENST00000342704	O43439 [Direct mapping] Protein CBFA2T2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	595 aa 65.9 kDa	No	0
CBFA2T2-201 ENSP00000262653 ENST00000346541	O43439 [Direct mapping] Protein CBFA2T2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0030855 [epithelial cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	604 aa 67.1 kDa	No	0
CBFA2T2-202 ENSP00000380902 ENST00000397800	O43439 [Direct mapping] Protein CBFA2T2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	575 aa 63.9 kDa	No	0
CBFA2T2-203 ENSP00000443398 ENST00000543126	Q68DC6 [Direct mapping] Protein CBFA2T2; Putative uncharacterized protein DKFZp313F2116 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	152 aa 16.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.