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TOLLIP

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GENERAL INFORMATION

Gene name

 TOLLIP

Gene description

 Toll interacting protein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA038621
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038621 U-2 OS Plasma membrane
Cytosol
HPA038621 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 TOLLIP (HGNC Symbol)

Synonyms

 IL-1RAcPIP

Description

 Toll interacting protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 1274371 - 1309654

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078902 (version 83.38)

Entrez gene

 54472

UniProt

 Q9H0E2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0E2

Antibodypedia

 TOLLIP antibodies

PROTEIN BROWSER
TOLLIP-001
TOLLIP-002
TOLLIP-003
TOLLIP-004
TOLLIP-005
TOLLIP-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOLLIP-001
ENSP00000314733
ENST00000317204
Q9H0E2 [Direct mapping]
Toll-interacting protein
Q6FIE9 [Target identity:100%; Query identity:100%]
TOLLIP protein; Toll interacting protein; Toll interacting protein, isoform CRA_a; cDNA, FLJ96670, Homo sapiens toll interacting protein (TOLLIP), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0016310 [phosphorylation]
GO:0016604 [nuclear body]
GO:0019900 [kinase binding]
GO:0030855 [epithelial cell differentiation]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032183 [SUMO binding]
GO:0033235 [positive regulation of protein sumoylation]
GO:0035325 [Toll-like receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0036010 [protein localization to endosome]
GO:0045087 [innate immune response]
GO:0045092 [interleukin-18 receptor complex]
GO:0045321 [leukocyte activation]
GO:0045323 [interleukin-1 receptor complex]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 274 aa
30.3 kDa 		No 0
TOLLIP-002
ENSP00000434035
ENST00000527886
Q9H0E2 [Direct mapping]
Toll-interacting protein
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0016310 [phosphorylation]
GO:0019900 [kinase binding]
GO:0030855 [epithelial cell differentiation]
GO:0035325 [Toll-like receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0036010 [protein localization to endosome]
GO:0045087 [innate immune response]
GO:0045092 [interleukin-18 receptor complex]
GO:0045321 [leukocyte activation]
GO:0045323 [interleukin-1 receptor complex]
GO:0070062 [extracellular exosome]
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 205 aa
22.8 kDa 		No 0
TOLLIP-003
ENSP00000432668
ENST00000525159
F2Z2Y8 [Direct mapping]
Toll-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 213 aa
23.3 kDa 		No 0
TOLLIP-004
ENSP00000263646
ENST00000263646
E7EN89 [Direct mapping]
Toll interacting protein, isoform CRA_b; Toll-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 246 aa
27 kDa 		No 0
TOLLIP-005
ENSP00000434494
ENST00000530541
E9PQ25 [Direct mapping]
Toll-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 186 aa
20.5 kDa 		No 0
TOLLIP-012
ENSP00000432778
ENST00000527938
E9PNS3 [Direct mapping]
Toll-interacting protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 80 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.