Cell atlas - RUNX1T1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RUNX1T1
Gene description	Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	34
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HEL, Daudi, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049852
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, Daudi, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049852	HEK 293	Nucleoplasm
	HPA049852	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Nucleoplasm

Additional location

Cytosol

Mouse gene

ENSMUSG00000006586 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049852	NIH 3T3	Nucleoplasm
	HPA049852	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	RUNX1T1 (HGNC Symbol)
Synonyms	AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
Description	Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Chromosome	8
Cytoband	q21.3
Chromosome location (bp)	91954967 - 92103286
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079102 (version 83.38)
Entrez gene	862
UniProt	Q06455 (UniProt - Evidence at protein level)
neXtProt	NX_Q06455
Antibodypedia	RUNX1T1 antibodies

PROTEIN BROWSER

RUNX1T1-001	RUNX1T1-002	RUNX1T1-004	RUNX1T1-006	RUNX1T1-009	RUNX1T1-010	RUNX1T1-011	RUNX1T1-012	RUNX1T1-016	RUNX1T1-017	RUNX1T1-018	RUNX1T1-019	RUNX1T1-020	RUNX1T1-023	RUNX1T1-025	RUNX1T1-028	RUNX1T1-029	RUNX1T1-030	RUNX1T1-031	RUNX1T1-032	RUNX1T1-033	RUNX1T1-034	RUNX1T1-038	RUNX1T1-039	RUNX1T1-040	RUNX1T1-041	RUNX1T1-042	RUNX1T1-201	RUNX1T1-202	RUNX1T1-203	RUNX1T1-204	RUNX1T1-205	RUNX1T1-206	RUNX1T1-207

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RUNX1T1-001 ENSP00000428543 ENST00000523629	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	604 aa 67.6 kDa	No	0
RUNX1T1-002 ENSP00000379520 ENST00000396218	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	577 aa 64.4 kDa	No	0
RUNX1T1-004 ENSP00000390137 ENST00000422361	Q06455 [Direct mapping] Protein CBFA2T1 W8FW32 [Target identity:100%; Query identity:100%] CBFA2T1 isoform r1t1-7d56; CBFA2T1 isoform r1t1-8a60 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	567 aa 63.2 kDa	No	0
RUNX1T1-006 ENSP00000429728 ENST00000521553	E5RHJ8 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	210 aa 22.7 kDa	No	0
RUNX1T1-009 ENSP00000353504 ENST00000360348	Q06455 [Direct mapping] Protein CBFA2T1 W8FW32 [Target identity:100%; Query identity:100%] CBFA2T1 isoform r1t1-7d56; CBFA2T1 isoform r1t1-8a60 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	567 aa 63.2 kDa	No	0
RUNX1T1-010 ENSP00000430728 ENST00000518844	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	577 aa 64.4 kDa	No	0
RUNX1T1-011 ENSP00000428742 ENST00000520724	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	615 aa 68.7 kDa	No	0
RUNX1T1-012 ENSP00000429864 ENST00000518832	E5RH72 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	46 aa 4.8 kDa	No	0
RUNX1T1-016 ENSP00000429118 ENST00000523168	E7ESA9 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	120 aa 12.6 kDa	No	0
RUNX1T1-017 ENSP00000429532 ENST00000522467	E7EQW3 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	156 aa 16.7 kDa	No	0
RUNX1T1-018 ENSP00000430204 ENST00000519847	E7EWJ9 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	169 aa 18.2 kDa	No	0
RUNX1T1-019 ENSP00000429506 ENST00000517919	E7EQW7 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	135 aa 14.5 kDa	No	0
RUNX1T1-020 ENSP00000429375 ENST00000520974	E7ERJ9 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	85 aa 9.4 kDa	No	0
RUNX1T1-023 ENSP00000430334 ENST00000519061	E5RFQ3 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	26 aa 3 kDa	No	0
RUNX1T1-025 ENSP00000430070 ENST00000520583	E7ESA9 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	120 aa 12.6 kDa	No	0
RUNX1T1-028 ENSP00000430080 ENST00000518954	E7EX23 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	54 aa 6.2 kDa	No	0
RUNX1T1-029 ENSP00000428475 ENST00000518823	E5RI38 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	79 aa 8.1 kDa	No	0
RUNX1T1-030 ENSP00000428133 ENST00000518449	E7EV92 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	58 aa 6.2 kDa	No	0
RUNX1T1-031 ENSP00000429666 ENST00000521375	E7EQI9 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	94 aa 10.2 kDa	No	0
RUNX1T1-032 ENSP00000429137 ENST00000521319	E5RJB3 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	89 aa 9 kDa	No	0
RUNX1T1-033 ENSP00000429062 ENST00000518317	E5RJE7 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	69 aa 7.2 kDa	No	0
RUNX1T1-034 ENSP00000429857 ENST00000520428	E7EQ59 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	48 aa 5.6 kDa	No	0
RUNX1T1-038 ENSP00000429940 ENST00000517792	E5RH30 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	120 aa 12.5 kDa	No	0
RUNX1T1-039 ENSP00000430637 ENST00000521733	E5RJ32 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	101 aa 10.5 kDa	No	0
RUNX1T1-040 ENSP00000427763 ENST00000521054	E5RG85 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	171 aa 18.3 kDa	No	0
RUNX1T1-041 ENSP00000428100 ENST00000520556	E5RK76 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	91 aa 9.3 kDa	No	0
RUNX1T1-042 ENSP00000431094 ENST00000518992	E7ETA8 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	229 aa 25 kDa	No	0
RUNX1T1-201 ENSP00000265814 ENST00000265814	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	604 aa 67.6 kDa	No	0
RUNX1T1-202 ENSP00000402257 ENST00000436581	A0A0A0MSU1 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0042803 [protein homodimerization activity] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0051101 [regulation of DNA binding] Show all	663 aa 74.2 kDa	No	0
RUNX1T1-203 ENSP00000481799 ENST00000613302	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	604 aa 67.6 kDa	No	0
RUNX1T1-204 ENSP00000478331 ENST00000613886	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	577 aa 64.4 kDa	No	0
RUNX1T1-205 ENSP00000481315 ENST00000614812	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	604 aa 67.6 kDa	No	0
RUNX1T1-206 ENSP00000480500 ENST00000615601	A0A087WWT6 [Direct mapping] Protein CBFA2T1; Runt-related transcription factor 1 translocated to, 1 (Cyclin D-related), isoform CRA_c Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	584 aa 65.1 kDa	No	0
RUNX1T1-207 ENSP00000481112 ENST00000617740	Q06455 [Direct mapping] Protein CBFA2T1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016363 [nuclear matrix] GO:0042802 [identical protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	604 aa 67.6 kDa	No	0