Cell atlas - SLC1A3 - The Human Protein Atlas

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SLC1A3

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoli

Human cell
	Mitochondria
	Nucleoli

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GENERAL INFORMATION
Gene name	SLC1A3
Gene description	Solute carrier family 1 (glial high affinity glutamate transporter), member 3
Protein class	Cancer-related genes Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoli.
RNA cell category	Cell line enhanced (CACO-2, HaCaT, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA037467
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2, HaCaT, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoli.

Main location

Mitochondria (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037467	A-431	Nucleoli
	HPA037467	A-431	Mitochondria
	HPA037467	U-2 OS	Nucleoli
	HPA037467	U-2 OS	Mitochondria
	HPA037467	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	SLC1A3 (HGNC Symbol)
Synonyms	EA6, EAAT1, GLAST
Description	Solute carrier family 1 (glial high affinity glutamate transporter), member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	36606355 - 36688334
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079215 (version 83.38)
Entrez gene	6507
UniProt	P43003 (UniProt - Evidence at protein level)
neXtProt	NX_P43003
Antibodypedia	SLC1A3 antibodies

PROTEIN BROWSER

SLC1A3-001	SLC1A3-007	SLC1A3-010	SLC1A3-011	SLC1A3-201	SLC1A3-202	SLC1A3-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC1A3-001 ENSP00000265113 ENST00000265113	P43003 [Direct mapping] Excitatory amino acid transporter 1 A0A024R050 [Target identity:100%; Query identity:100%] Amino acid transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001504 [neurotransmitter uptake] GO:0002230 [positive regulation of defense response to virus by host] GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005314 [high-affinity glutamate transmembrane transporter activity] GO:0005515 [protein binding] GO:0005743 [mitochondrial inner membrane] GO:0005886 [plasma membrane] GO:0006536 [glutamate metabolic process] GO:0006537 [glutamate biosynthetic process] GO:0006811 [ion transport] GO:0006835 [dicarboxylic acid transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007605 [sensory perception of sound] GO:0009416 [response to light stimulus] GO:0009449 [gamma-aminobutyric acid biosynthetic process] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0014047 [glutamate secretion] GO:0015813 [L-glutamate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016595 [glutamate binding] GO:0016597 [amino acid binding] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0021545 [cranial nerve development] GO:0031223 [auditory behavior] GO:0042493 [response to drug] GO:0042995 [cell projection] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0043205 [fibril] GO:0043490 [malate-aspartate shuttle] GO:0045202 [synapse] GO:0046677 [response to antibiotic] GO:0048667 [cell morphogenesis involved in neuron differentiation] GO:0050806 [positive regulation of synaptic transmission] GO:0050885 [neuromuscular process controlling balance] GO:0051938 [L-glutamate import] GO:0055085 [transmembrane transport] GO:0070779 [D-aspartate import] GO:0071944 [cell periphery] GO:0089711 [L-glutamate transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	542 aa 59.6 kDa	No	>9
SLC1A3-007 ENSP00000427203 ENST00000513903	E7EUS7 [Direct mapping] Excitatory amino acid transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] Show all	101 aa 11.8 kDa	No	1
SLC1A3-010 ENSP00000424986 ENST00000505202	E7EUV6 [Direct mapping] Amino acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] Show all	107 aa 12.3 kDa	No	2
SLC1A3-011 ENSP00000420992 ENST00000513646	E7EUV6 [Direct mapping] Amino acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] Show all	107 aa 12.3 kDa	No	2
SLC1A3-201 ENSP00000371343 ENST00000381918	P43003 [Direct mapping] Excitatory amino acid transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001504 [neurotransmitter uptake] GO:0002230 [positive regulation of defense response to virus by host] GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006835 [dicarboxylic acid transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0014047 [glutamate secretion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0051938 [L-glutamate import] GO:0055085 [transmembrane transport] GO:0070779 [D-aspartate import] GO:0089711 [L-glutamate transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	497 aa 55.1 kDa	No	8
SLC1A3-202 ENSP00000483657 ENST00000612708	A0A087X0U3 [Direct mapping] Amino acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] Show all	430 aa 47.1 kDa	No	>9
SLC1A3-203 ENSP00000477672 ENST00000613445	A0A087WT87 [Direct mapping] Amino acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] Show all	496 aa 54.2 kDa	No	9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.