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XRCC5

GENERAL INFORMATION

Gene name

 XRCC5

Gene description

 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA025813 , CAB004468
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 XRCC5 (HGNC Symbol)

Synonyms

 KARP-1, KU80, Ku86, KUB2

Description

 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 216107464 - 216206303

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079246 (version 83.38)

Entrez gene

 7520

UniProt

 P13010 (UniProt - Evidence at protein level)

neXtProt

 NX_P13010

Antibodypedia

 XRCC5 antibodies

PROTEIN BROWSER
XRCC5-001
XRCC5-003
XRCC5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XRCC5-001
ENSP00000375978
ENST00000392133
P13010 [Direct mapping]
X-ray repair cross-complementing protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0032508 [DNA duplex unwinding]
GO:0042162 [telomeric DNA binding]
GO:0043564 [Ku70:Ku80 complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0060218 [hematopoietic stem cell differentiation]
GO:0070419 [nonhomologous end joining complex]
GO:0071480 [cellular response to gamma radiation]
GO:0071481 [cellular response to X-ray]
GO:0075713 [establishment of integrated proviral latency]
Show all
 732 aa
82.7 kDa 		No 0
XRCC5-003
ENSP00000401318
ENST00000417391
C9JZ81 [Direct mapping]
X-ray repair cross-complementing protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 131 aa
14.8 kDa 		No 0
XRCC5-201
ENSP00000375977
ENST00000392132
P13010 [Direct mapping]
X-ray repair cross-complementing protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000723 [telomere maintenance]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0008022 [protein C-terminus binding]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0032508 [DNA duplex unwinding]
GO:0042162 [telomeric DNA binding]
GO:0043564 [Ku70:Ku80 complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0070419 [nonhomologous end joining complex]
GO:0071480 [cellular response to gamma radiation]
GO:0071481 [cellular response to X-ray]
GO:0075713 [establishment of integrated proviral latency]
Show all
 732 aa
82.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.