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SENP1

CANCER ATLAS

Gene description

 SUMO1/sentrin specific peptidase 1

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011765

GENE INFORMATION

Gene name

 SENP1

Synonyms

Description

 SUMO1/sentrin specific peptidase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Chromosome

 12

Cytoband

 q13.11

Chromosome location (bp)

 48042898 - 48106308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079387 (version 83.38)

Entrez gene

 29843

UniProt

 Q9P0U3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P0U3

Antibodypedia

 SENP1 antibodies

PROTEIN BROWSER
SENP1-002
SENP1-003
SENP1-004
SENP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SENP1-002
ENSP00000394791
ENST00000448372
Q9P0U3 [Direct mapping]
Sentrin-specific protease 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0010724 [regulation of definitive erythrocyte differentiation]
GO:0016925 [protein sumoylation]
GO:0016926 [protein desumoylation]
GO:0016929 [SUMO-specific protease activity]
GO:0031965 [nuclear membrane]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0097190 [apoptotic signaling pathway]
Show all
 644 aa
73.5 kDa 		No 0
SENP1-003
ENSP00000450076
ENST00000549595
Q9P0U3 [Direct mapping]
Sentrin-specific protease 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0016925 [protein sumoylation]
GO:0016926 [protein desumoylation]
GO:0016929 [SUMO-specific protease activity]
GO:0031965 [nuclear membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0097190 [apoptotic signaling pathway]
Show all
 643 aa
73.4 kDa 		No 0
SENP1-004
ENSP00000447328
ENST00000549518
Q9P0U3 [Direct mapping]
Sentrin-specific protease 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0016925 [protein sumoylation]
GO:0016926 [protein desumoylation]
GO:0016929 [SUMO-specific protease activity]
GO:0031965 [nuclear membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0097190 [apoptotic signaling pathway]
Show all
 644 aa
73.5 kDa 		No 0
SENP1-006
ENSP00000448597
ENST00000551798
F8VRZ8 [Direct mapping]
Sentrin-specific protease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
15.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.