Tissue expression of DUSP13 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DUSP13
Gene description	Dual specificity phosphatase 13
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (skeletal muscle, testis)
GTEx:	Group enriched (skeletal muscle, testis)
FANTOM5:	Group enriched (skeletal muscle, testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (skeletal muscle, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (skeletal muscle, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (skeletal muscle, testis)

GENE INFORMATION
Gene name	DUSP13 (HGNC Symbol)
Synonyms	BEDP, DUSP13A, DUSP13B, FLJ32450, TMDP
Description	Dual specificity phosphatase 13 (HGNC Symbol)
Entrez gene summary	Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q22.2
Chromosome location (bp)	75094432 - 75109221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079393 (version 83.38)
Entrez gene	51207
UniProt	Q6B8I1 (UniProt - Evidence at protein level), Q9UII6 (UniProt - Evidence at protein level)
neXtProt	NX_Q6B8I1, NX_Q9UII6
Antibodypedia	DUSP13 antibodies

PROTEIN BROWSER

DUSP13-002	DUSP13-004	DUSP13-007	DUSP13-008	DUSP13-009	DUSP13-011	DUSP13-012	DUSP13-013	DUSP13-201	DUSP13-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DUSP13-002 ENSP00000475675 ENST00000605915	U3KQA1 [Direct mapping] Dual-specificity protein phosphatase 13 isoform B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	220 aa 24.7 kDa	No	0
DUSP13-004 ENSP00000444580 ENST00000472493	Q9UII6 [Direct mapping] Dual specificity protein phosphatase 13 isoform B A0A024QZR6 [Target identity:100%; Query identity:100%] Dual specificity phosphatase 13, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0007126 [meiotic nuclear division] GO:0007283 [spermatogenesis] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	198 aa 22.1 kDa	No	0
DUSP13-007 ENSP00000434041 ENST00000464872	E9PSD4 [Direct mapping] Dual-specificity protein phosphatase 13 isoform B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	147 aa 16.3 kDa	No	0
DUSP13-008 ENSP00000475732 ENST00000473072	U3KQB7 [Direct mapping] Dual-specificity protein phosphatase 13 isoform B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	193 aa 20.1 kDa	No	1
DUSP13-009 ENSP00000475626 ENST00000478873	U3KQ82 [Direct mapping] Dual-specificity protein phosphatase 13 isoform B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	334 aa 37.4 kDa	No	0
DUSP13-011 ENSP00000361785 ENST00000372700	Q9UII6 [Direct mapping] Dual specificity protein phosphatase 13 isoform B Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0007126 [meiotic nuclear division] GO:0007283 [spermatogenesis] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	248 aa 27.5 kDa	No	0
DUSP13-012 ENSP00000361787 ENST00000372702	Q6B8I1 [Direct mapping] Dual specificity protein phosphatase 13 isoform A Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005737 [cytoplasm] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	188 aa 20.7 kDa	No	0
DUSP13-013 ENSP00000475851 ENST00000607487	U3KQG1 [Direct mapping] Dual-specificity protein phosphatase 13 isoform B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] Show all	260 aa 27.7 kDa	No	1
DUSP13-201 ENSP00000436312 ENST00000491677	Q9UII6 [Direct mapping] Dual specificity protein phosphatase 13 isoform B A0A024QZR6 [Target identity:100%; Query identity:100%] Dual specificity phosphatase 13, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0007126 [meiotic nuclear division] GO:0007283 [spermatogenesis] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	198 aa 22.1 kDa	No	0
DUSP13-202 ENSP00000475801 ENST00000607131	Q9UII6 [Direct mapping] Dual specificity protein phosphatase 13 isoform B A0A024QZR6 [Target identity:100%; Query identity:100%] Dual specificity phosphatase 13, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0007126 [meiotic nuclear division] GO:0007283 [spermatogenesis] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	198 aa 22.1 kDa	No	0