Expression of FDFT1 in cancer - Summary

CANCER ATLAS

Gene description

Farnesyl-diphosphate farnesyltransferase 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008874

GENE INFORMATION
Gene name	FDFT1
Synonyms
Description	Farnesyl-diphosphate farnesyltransferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	11795573 - 11839309
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079459 (version 83.38)
Entrez gene	2222
UniProt	P37268 (UniProt - Evidence at protein level)
neXtProt	NX_P37268
Antibodypedia	FDFT1 antibodies

PROTEIN BROWSER

FDFT1-001	FDFT1-002	FDFT1-006	FDFT1-007	FDFT1-009	FDFT1-011	FDFT1-012	FDFT1-018	FDFT1-201	FDFT1-202	FDFT1-203	FDFT1-204	FDFT1-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FDFT1-001 ENSP00000220584 ENST00000220584	P37268 [Direct mapping] Squalene synthase Q6IAX1 [Target identity:100%; Query identity:100%] FDFT1 protein; Farnesyl-diphosphate farnesyltransferase 1; Farnesyl-diphosphate farnesyltransferase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	417 aa 48.1 kDa	No	1
FDFT1-002 ENSP00000390367 ENST00000443614	P37268 [Direct mapping] Squalene synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	374 aa 43.1 kDa	No	1
FDFT1-006 ENSP00000434714 ENST00000525900	E9PNM1 [Direct mapping] Squalene synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	410 aa 47.3 kDa	No	1
FDFT1-007 ENSP00000431749 ENST00000528812	P37268 [Direct mapping] Squalene synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	353 aa 40.8 kDa	No	1
FDFT1-009 ENSP00000432331 ENST00000530664	P37268 [Direct mapping] Squalene synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	353 aa 40.8 kDa	No	1
FDFT1-011 ENSP00000431649 ENST00000528643	P37268 [Direct mapping] Squalene synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	332 aa 38.3 kDa	No	1
FDFT1-012 ENSP00000431852 ENST00000530337	E9PJG4 [Direct mapping] Squalene synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0009058 [biosynthetic process] GO:0016740 [transferase activity] Show all	150 aa 17.7 kDa	No	0
FDFT1-018 ENSP00000436069 ENST00000525777	P37268 [Direct mapping] Squalene synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	332 aa 38.3 kDa	No	1
FDFT1-201 ENSP00000444248 ENST00000538689	P37268 [Direct mapping] Squalene synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	353 aa 40.8 kDa	No	2
FDFT1-202 ENSP00000481481 ENST00000615631	P37268 [Direct mapping] Squalene synthase Q6IAX1 [Target identity:100%; Query identity:100%] FDFT1 protein; Farnesyl-diphosphate farnesyltransferase 1; Farnesyl-diphosphate farnesyltransferase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	417 aa 48.1 kDa	No	1
FDFT1-203 ENSP00000480828 ENST00000618539	P37268 [Direct mapping] Squalene synthase Q6IAX1 [Target identity:100%; Query identity:100%] FDFT1 protein; Farnesyl-diphosphate farnesyltransferase 1; Farnesyl-diphosphate farnesyltransferase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045338 [farnesyl diphosphate metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	417 aa 48.1 kDa	No	1
FDFT1-204 ENSP00000484122 ENST00000622850	P37268 [Direct mapping] Squalene synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	353 aa 40.8 kDa	No	2
FDFT1-205 ENSP00000485229 ENST00000623368	P37268 [Direct mapping] Squalene synthase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004310 [farnesyl-diphosphate farnesyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0008610 [lipid biosynthetic process] GO:0009058 [biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016740 [transferase activity] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051996 [squalene synthase activity] GO:0055114 [oxidation-reduction process] Show all	353 aa 40.8 kDa	No	2