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KEAP1

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GENERAL INFORMATION

Gene name

 KEAP1

Gene description

 Kelch-like ECH-associated protein 1

Protein class

 Cancer-related genes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the microtubule organizing center & nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Microtubule organizing center (approved)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA005558
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the microtubule organizing center & nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported), Microtubule organizing center (approved)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA005558 A-431 Nucleoplasm
Microtubule organizing center
HPA005558 U-2 OS Nucleoplasm
Cytosol
HPA005558 U-251 MG Nucleoplasm
Microtubule organizing center
Cytosol

GENE INFORMATION

Gene name

 KEAP1 (HGNC Symbol)

Synonyms

 INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454

Description

 Kelch-like ECH-associated protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10486120 - 10503741

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079999 (version 83.38)

Entrez gene

 9817

UniProt

 Q14145 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14145

Antibodypedia

 KEAP1 antibodies

PROTEIN BROWSER
KEAP1-001
KEAP1-002
KEAP1-003
KEAP1-004
KEAP1-005
KEAP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KEAP1-001
ENSP00000171111
ENST00000171111
Q14145 [Direct mapping]
Kelch-like ECH-associated protein 1
A0A024R7C0 [Target identity:100%; Query identity:100%]
Kelch-like ECH-associated protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0001887 [selenium compound metabolic process]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0006108 [malate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0009812 [flavonoid metabolic process]
GO:0010038 [response to metal ion]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0010629 [negative regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019694 [alkanesulfonate metabolic process]
GO:0030496 [midbody]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035902 [response to immobilization stress]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045604 [regulation of epidermal cell differentiation]
GO:0051259 [protein oligomerization]
GO:0071353 [cellular response to interleukin-4]
GO:0071407 [cellular response to organic cyclic compound]
GO:0097066 [response to thyroid hormone]
Show all
 624 aa
69.7 kDa 		No 0
KEAP1-002
ENSP00000377245
ENST00000393623
Q14145 [Direct mapping]
Kelch-like ECH-associated protein 1
A0A024R7C0 [Target identity:100%; Query identity:100%]
Kelch-like ECH-associated protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0030496 [midbody]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
Show all
 624 aa
69.7 kDa 		No 0
KEAP1-003
ENSP00000468014
ENST00000592478
K7EQX2 [Direct mapping]
Kelch-like ECH-associated protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008134 [transcription factor binding]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 172 aa
19 kDa 		No 0
KEAP1-004
ENSP00000468671
ENST00000592055
K7ESE0 [Direct mapping]
Kelch-like ECH-associated protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0008134 [transcription factor binding]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 279 aa
31.4 kDa 		No 0
KEAP1-005
ENSP00000465126
ENST00000591419
K7EJD8 [Direct mapping]
Kelch-like ECH-associated protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0008134 [transcription factor binding]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 213 aa
23.5 kDa 		No 0
KEAP1-006
ENSP00000465024
ENST00000591039
K7EJ49 [Direct mapping]
Kelch-like ECH-associated protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0008134 [transcription factor binding]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 212 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.