We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
DCT
  • premium

    TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

DCT

Gene description

Dopachrome tautomerase

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (skin)
GTEx:Tissue enriched (skin)
FANTOM5:Tissue enriched (retina)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in melanocytes.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA010743 , HPA010800 , CAB017634
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

DCT (HGNC Symbol)

Synonyms

TYRP2

Description

Dopachrome tautomerase (HGNC Symbol)

Entrez gene summary

Chromosome

13

Cytoband

q32.1

Chromosome location (bp)

94436808 - 94479682

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080166 (version 83.38)

Entrez gene

1638

UniProt

P40126 (UniProt - Evidence at protein level)

neXtProt

NX_P40126

Antibodypedia

DCT antibodies

PROTEIN BROWSER

DCT-001
DCT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCT-001
ENSP00000366227
ENST00000377028
P40126 [Direct mapping]
L-dopachrome tautomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004167 [dopachrome isomerase activity]
GO:0005507 [copper ion binding]
GO:0005829 [cytosol]
GO:0006583 [melanin biosynthetic process from tyrosine]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042438 [melanin biosynthetic process]
GO:0042470 [melanosome]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
519 aa
59.1 kDa
Yes 1
DCT-201
ENSP00000392762
ENST00000446125
P40126 [Direct mapping]
L-dopachrome tautomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004167 [dopachrome isomerase activity]
GO:0005507 [copper ion binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006583 [melanin biosynthetic process from tyrosine]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0021847 [ventricular zone neuroblast division]
GO:0033162 [melanosome membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042438 [melanin biosynthetic process]
GO:0042470 [melanosome]
GO:0043473 [pigmentation]
GO:0044281 [small molecule metabolic process]
GO:0048066 [developmental pigmentation]
GO:0048468 [cell development]
GO:0055114 [oxidation-reduction process]
Show all
552 aa
62.9 kDa
Yes 1

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.