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RFX3

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GENERAL INFORMATION

Gene name

 RFX3

Gene description

 Regulatory factor X, 3 (influences HLA class II expression)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to vesicles.

RNA cell category

 Cell line enhanced (AF22, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA035689
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to vesicles.

Main location

 Nucleoplasm (approved)

Additional location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035689 A-431 Nucleoplasm
HPA035689 U-2 OS Nucleoplasm
Vesicles
HPA035689 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 RFX3

Synonyms

Description

 Regulatory factor X, 3 (influences HLA class II expression) (HGNC Symbol)

Entrez gene summary

 This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Chromosome

 9

Cytoband

 p24.2

Chromosome location (bp)

 3218297 - 3526004

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080298 (version 83.38)

Entrez gene

 5991

UniProt

 P48380 (UniProt - Evidence at protein level)

neXtProt

 NX_P48380

Antibodypedia

 RFX3 antibodies

PROTEIN BROWSER
«
RFX3-001
RFX3-002
RFX3-003
RFX3-004
RFX3-005
RFX3-006
RFX3-007
RFX3-008
RFX3-009
RFX3-010
RFX3-201
RFX3-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RFX3-001
ENSP00000371414
ENST00000381984
A9Z1Z2 [Direct mapping]
Transcription factor RFX3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042384 [cilium assembly]
Show all
 85 aa
9.1 kDa 		No 0
RFX3-002
ENSP00000411756
ENST00000451859
F6UV76 [Direct mapping]
Transcription factor RFX3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042384 [cilium assembly]
Show all
 184 aa
19.4 kDa 		No 0
RFX3-003
ENSP00000405664
ENST00000457373
F6UGA0 [Direct mapping]
Transcription factor RFX3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042384 [cilium assembly]
Show all
 216 aa
23.4 kDa 		No 0
RFX3-004
ENSP00000399352
ENST00000449190
F6XM74 [Direct mapping]
Transcription factor RFX3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042384 [cilium assembly]
Show all
 138 aa
14.5 kDa 		No 0
RFX3-005
ENSP00000351574
ENST00000358730
P48380 [Direct mapping]
Transcription factor RFX3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0031018 [endocrine pancreas development]
GO:0042384 [cilium assembly]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048469 [cell maturation]
GO:0050796 [regulation of insulin secretion]
GO:0060285 [cilium-dependent cell motility]
GO:0060287 [epithelial cilium movement involved in determination of left/right asymmetry]
GO:2000078 [positive regulation of type B pancreatic cell development]
Show all
 707 aa
79.4 kDa 		No 0
RFX3-006
ENSP00000371434
ENST00000382004
P48380 [Direct mapping]
Transcription factor RFX3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007368 [determination of left/right symmetry]
GO:0031018 [endocrine pancreas development]
GO:0042384 [cilium assembly]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048469 [cell maturation]
GO:0050796 [regulation of insulin secretion]
GO:0060285 [cilium-dependent cell motility]
GO:0060287 [epithelial cilium movement involved in determination of left/right asymmetry]
GO:0072560 [type B pancreatic cell maturation]
GO:2000078 [positive regulation of type B pancreatic cell development]
Show all
 749 aa
83.5 kDa 		No 0
RFX3-007
ENSP00000415594
ENST00000449234
H0Y7W5 [Direct mapping]
Transcription factor RFX3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042384 [cilium assembly]
Show all
 124 aa
14.5 kDa 		No 0
RFX3-008
ENSP00000400026
ENST00000458034
F6USP3 [Direct mapping]
Transcription factor RFX3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042384 [cilium assembly]
Show all
 174 aa
19.9 kDa 		No 0
RFX3-009
ENSP00000410988
ENST00000442560
H0Y790 [Direct mapping]
Transcription factor RFX3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042384 [cilium assembly]
Show all
 135 aa
14.3 kDa 		No 0
RFX3-010
ENSP00000416189
ENST00000420720
H0Y7Z4 [Direct mapping]
Transcription factor RFX3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042384 [cilium assembly]
Show all
 156 aa
16.7 kDa 		No 0
RFX3-201
ENSP00000303847
ENST00000302303
P48380 [Direct mapping]
Transcription factor RFX3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0031018 [endocrine pancreas development]
GO:0042384 [cilium assembly]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048469 [cell maturation]
GO:0050796 [regulation of insulin secretion]
GO:0060285 [cilium-dependent cell motility]
GO:0060287 [epithelial cilium movement involved in determination of left/right asymmetry]
GO:2000078 [positive regulation of type B pancreatic cell development]
Show all
 413 aa
45.7 kDa 		No 0
RFX3-202
ENSP00000482598
ENST00000617270
P48380 [Direct mapping]
Transcription factor RFX3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0031018 [endocrine pancreas development]
GO:0042384 [cilium assembly]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048469 [cell maturation]
GO:0050796 [regulation of insulin secretion]
GO:0060285 [cilium-dependent cell motility]
GO:0060287 [epithelial cilium movement involved in determination of left/right asymmetry]
GO:2000078 [positive regulation of type B pancreatic cell development]
Show all
 749 aa
83.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.