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SLC4A4

GENERAL INFORMATION

Gene name

 SLC4A4

Gene description

 Solute carrier family 4 (sodium bicarbonate cotransporter), member 4

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
GTEx:Tissue enhanced (pancreas)
FANTOM5:Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in several tissues, most abundant in pancreatic ductal cells and cells in renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA035628 , HPA035629 , CAB022493
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

 SLC4A4 (HGNC Symbol)

Synonyms

 hhNMC, HNBC1, NBC1, NBC2, pNBC, SLC4A5

Description

 Solute carrier family 4 (sodium bicarbonate cotransporter), member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 71187286 - 71572087

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080493 (version 83.38)

Entrez gene

 8671

UniProt

 Q9Y6R1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6R1

Antibodypedia

 SLC4A4 antibodies

PROTEIN BROWSER
SLC4A4-001
SLC4A4-002
SLC4A4-003
SLC4A4-004
SLC4A4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC4A4-001
ENSP00000344272
ENST00000340595
Q9Y6R1 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
Show all
 1035 aa
116 kDa 		No >9
SLC4A4-002
ENSP00000264485
ENST00000264485
Q9Y6R1 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 1
A0A024RD97 [Target identity:100%; Query identity:100%]
Anion exchange protein
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
Show all
 1079 aa
121.5 kDa 		No >9
SLC4A4-003
ENSP00000307349
ENST00000351898
Q9Y6R1 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
Show all
 995 aa
112.3 kDa 		No 9
SLC4A4-004
ENSP00000422400
ENST00000512686
Q9Y6R1 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
Show all
 646 aa
72 kDa 		No 4
SLC4A4-201
ENSP00000393557
ENST00000425175
Q9Y6R1 [Direct mapping]
Electrogenic sodium bicarbonate cotransporter 1
A5JJ20 [Target identity:100%; Query identity:100%]
Anion exchange protein
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098656 [anion transmembrane transport]
Show all
 1094 aa
123.2 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.