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SMARCA2

CANCER ATLAS

Gene description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029981
CAB037276

GENE INFORMATION

Gene name

 SMARCA2 (HGNC Symbol)

Synonyms

 BAF190, BRM, hBRM, hSNF2a, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2

Description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

Chromosome

 9

Cytoband

 p24.3

Chromosome location (bp)

 2015219 - 2193624

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080503 (version 83.38)

Entrez gene

 6595

UniProt

 P51531 (UniProt - Evidence at protein level)

neXtProt

 NX_P51531

Antibodypedia

 SMARCA2 antibodies

PROTEIN BROWSER
«
SMARCA2-001
SMARCA2-002
SMARCA2-003
SMARCA2-004
SMARCA2-005
SMARCA2-006
SMARCA2-008
SMARCA2-010
SMARCA2-011
SMARCA2-012
SMARCA2-013
SMARCA2-014
SMARCA2-015
SMARCA2-017
SMARCA2-019
SMARCA2-022
SMARCA2-023
SMARCA2-027
SMARCA2-030
SMARCA2-032
SMARCA2-033
SMARCA2-034
SMARCA2-035
SMARCA2-036
SMARCA2-037
SMARCA2-038
SMARCA2-040
SMARCA2-041
SMARCA2-042
SMARCA2-044
SMARCA2-047
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMARCA2-001
ENSP00000305411
ENST00000302401
B1ALF6 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 278 aa
32 kDa 		Yes 0
SMARCA2-002
ENSP00000489302
ENST00000634781
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 260 aa
30.2 kDa 		No 0
SMARCA2-003
ENSP00000371638
ENST00000382203
P51531 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007286 [spermatid development]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030308 [negative regulation of cell growth]
GO:0035887 [aortic smooth muscle cell differentiation]
GO:0042393 [histone binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:0090544 [BAF-type complex]
Show all
 1590 aa
181.3 kDa 		No 0
SMARCA2-004
ENSP00000371629
ENST00000382194
P51531 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030308 [negative regulation of cell growth]
GO:0042393 [histone binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
Show all
 1572 aa
179.3 kDa 		No 0
SMARCA2-005
ENSP00000409398
ENST00000439732
A0A0A0MT03 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 215 aa
22.1 kDa 		No 0
SMARCA2-006
ENSP00000415218
ENST00000457226
F6RS74 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 193 aa
19.7 kDa 		No 0
SMARCA2-008
ENSP00000392081
ENST00000450198
F6VDE0 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0016887 [ATPase activity]
GO:0042393 [histone binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 1514 aa
172.6 kDa 		No 0
SMARCA2-010
ENSP00000371621
ENST00000382186
B1ALG2 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 254 aa
29.5 kDa 		No 0
SMARCA2-011
ENSP00000401096
ENST00000452193
A0A0A0MSS5 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 183 aa
21.4 kDa 		No 0
SMARCA2-012
ENSP00000387486
ENST00000417599
F6XG14 [Direct mapping]
Probable global transcription activator SNF2L2
B4DNT1 [Target identity:100%; Query identity:100%]
cDNA FLJ61143, highly similar to Probable global transcription activator SNF2L2 (EC 3.6.1.-)
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 276 aa
31.7 kDa 		Yes 0
SMARCA2-013
ENSP00000371618
ENST00000382183
B1ALG1 [Direct mapping]
Probable global transcription activator SNF2L2; cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2 (EC 3.6.1.-)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 236 aa
27.5 kDa 		No 0
SMARCA2-014
ENSP00000413057
ENST00000423555
F6XE55 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 228 aa
26.4 kDa 		Yes 0
SMARCA2-015
ENSP00000412242
ENST00000416751
F6UH26 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 192 aa
22.6 kDa 		No 0
SMARCA2-017
ENSP00000265773
ENST00000349721
P51531 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030308 [negative regulation of cell growth]
GO:0042393 [histone binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
Show all
 1590 aa
181.3 kDa 		No 0
SMARCA2-019
ENSP00000349788
ENST00000357248
P51531 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003713 [transcription coactivator activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0016514 [SWI/SNF complex]
GO:0016817 [hydrolase activity, acting on acid anhydrides]
GO:0030308 [negative regulation of cell growth]
GO:0042393 [histone binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
Show all
 1572 aa
179.3 kDa 		No 0
SMARCA2-022
ENSP00000324770
ENST00000324954
F6T8Q0 [Direct mapping]
Probable global transcription activator SNF2L2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 248 aa
28.9 kDa 		No 0
SMARCA2-023
ENSP00000371620
ENST00000382185
B1ALG1 [Direct mapping]
Probable global transcription activator SNF2L2; cDNA FLJ59976, highly similar to Probable global transcription activator SNF2L2 (EC 3.6.1.-)
B4DNT1 [Target identity:100%; Query identity:100%]
cDNA FLJ61143, highly similar to Probable global transcription activator SNF2L2 (EC 3.6.1.-)
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008152 [metabolic process]
GO:0016514 [SWI/SNF complex]
GO:0016887 [ATPase activity]
Show all
 276 aa
31.7 kDa 		Yes 0
SMARCA2-027
ENSP00000489560
ENST00000635226
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 57 aa
6.1 kDa 		No 0
SMARCA2-030
ENSP00000488947
ENST00000635185
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 228 aa
26.2 kDa 		No 0
SMARCA2-032
ENSP00000489518
ENST00000634772
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0042393 [histone binding]
Show all
 270 aa
32.1 kDa 		No 0
SMARCA2-033
ENSP00000489168
ENST00000635133
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 200 aa
23.1 kDa 		Yes 0
SMARCA2-034
ENSP00000489433
ENST00000634931
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 254 aa
29.5 kDa 		No 0
SMARCA2-035
ENSP00000489271
ENST00000635388
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 202 aa
23.7 kDa 		No 0
SMARCA2-036
ENSP00000489504
ENST00000634706
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 169 aa
20 kDa 		No 0
SMARCA2-037
ENSP00000489555
ENST00000635688
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 68 aa
7.9 kDa 		No 0
SMARCA2-038
ENSP00000489615
ENST00000634343
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 232 aa
26.9 kDa 		No 0
SMARCA2-040
ENSP00000489212
ENST00000634435
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 245 aa
28.3 kDa 		Yes 0
SMARCA2-041
ENSP00000489388
ENST00000634338
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 244 aa
28.1 kDa 		Yes 0
SMARCA2-042
ENSP00000489204
ENST00000635530
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 229 aa
26.5 kDa 		Yes 0
SMARCA2-044
ENSP00000489473
ENST00000634688
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 149 aa
17.6 kDa 		No 0
SMARCA2-047
ENSP00000489142
ENST00000634287
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 62 aa
6.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.