Tissue expression of RDH8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RDH8
Gene description	Retinol dehydrogenase 8 (all-trans)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (testis, kidney)
GTEx:	Group enriched (testis, kidney)
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	RDH8 (HGNC Symbol)
Synonyms	PRRDH, SDR28C2
Description	Retinol dehydrogenase 8 (all-trans) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. [provided by RefSeq, Feb 2014]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10013249 - 10022279
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000080511 (version 83.38)
Entrez gene	50700
UniProt
neXtProt
Antibodypedia	RDH8 antibodies

PROTEIN BROWSER

RDH8-001	RDH8-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RDH8-001 ENSP00000466058 ENST00000591589	K7ELF7 [Direct mapping] Retinol dehydrogenase 8 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004303 [estradiol 17-beta-dehydrogenase activity] GO:0004745 [retinol dehydrogenase activity] GO:0005737 [cytoplasm] GO:0006703 [estrogen biosynthetic process] GO:0007601 [visual perception] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0042572 [retinol metabolic process] GO:0055114 [oxidation-reduction process] Show all	331 aa 35.8 kDa	No	0
RDH8-002 ENSP00000465773 ENST00000587782	K7EKT5 [Direct mapping] Retinol dehydrogenase 8 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		79 aa 8.8 kDa	Yes	0