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COL5A3

GENERAL INFORMATION

Gene name

 COL5A3

Gene description

 Collagen, type V, alpha 3

Protein class

 Cancer-related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA048256
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)

GENE INFORMATION

Gene name

 COL5A3

Synonyms

Description

 Collagen, type V, alpha 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 9959561 - 10010471

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080573 (version 83.38)

Entrez gene

 50509

UniProt

 P25940 (UniProt - Evidence at protein level)

neXtProt

 NX_P25940

Antibodypedia

 COL5A3 antibodies

PROTEIN BROWSER
COL5A3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COL5A3-001
ENSP00000264828
ENST00000264828
P25940 [Direct mapping]
Collagen alpha-3(V) chain
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005201 [extracellular matrix structural constituent]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005588 [collagen type V trimer]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007160 [cell-matrix adhesion]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0043394 [proteoglycan binding]
GO:0043588 [skin development]
GO:0070062 [extracellular exosome]
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 1745 aa
172.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.