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Most of the cancer tissues displayed weak to moderate nuclear and cytoplasmic positivity. Several cases of lymphomas as well as lung, renal and liver cancers were negative.
GENE INFORMATION
Gene name
SRCAP (HGNC Symbol)
Synonyms
DOMO1, EAF1, KIAA0309, SWR1
Description
Snf2-related CREBBP activator protein (HGNC Symbol)
Entrez gene summary
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)