Expression of KCNN2 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2

Protein class

Plasma proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038221

GENE INFORMATION
Gene name	KCNN2 (HGNC Symbol)
Synonyms	hSK2, KCa2.2
Description	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 (HGNC Symbol)
Entrez gene summary	Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	5
Cytoband	q22.3
Chromosome location (bp)	114360945 - 114496500
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080709 (version 83.38)
Entrez gene	3781
UniProt	Q9H2S1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2S1
Antibodypedia	KCNN2 antibodies

PROTEIN BROWSER

KCNN2-001	KCNN2-002	KCNN2-006	KCNN2-201	KCNN2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNN2-001 ENSP00000427120 ENST00000512097	Q9H2S1 [Direct mapping] Small conductance calcium-activated potassium channel protein 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005516 [calmodulin binding] GO:0005790 [smooth endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0019904 [protein domain specific binding] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0042383 [sarcolemma] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0051393 [alpha-actinin binding] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	579 aa 63.8 kDa	No	7
KCNN2-002 ENSP00000421439 ENST00000503706	Q9H2S1 [Direct mapping] Small conductance calcium-activated potassium channel protein 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0019904 [protein domain specific binding] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0051393 [alpha-actinin binding] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	231 aa 26.3 kDa	No	1
KCNN2-006 ENSP00000487849 ENST00000631899		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] Show all	582 aa 64.1 kDa	No	7
KCNN2-201 ENSP00000264773 ENST00000264773	Q9H2S1 [Direct mapping] Small conductance calcium-activated potassium channel protein 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0019904 [protein domain specific binding] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0051393 [alpha-actinin binding] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	579 aa 63.8 kDa	No	7
KCNN2-202 ENSP00000483124 ENST00000610748	Q9H2S1 [Direct mapping] Small conductance calcium-activated potassium channel protein 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0019904 [protein domain specific binding] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0051393 [alpha-actinin binding] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	231 aa 26.3 kDa	No	1