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CPOX

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GENERAL INFORMATION

Gene name

 CPOX

Gene description

 Coproporphyrinogen oxidase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA015736 , HPA054448
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria.

Main location

 Mitochondria (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA015736 SK-MEL-30 Mitochondria Intensity
HPA015736 U-2 OS Mitochondria Intensity
HPA015736 U-251 MG Mitochondria
Cytosol
HPA054448 A-431 No staining    
HPA054448 U-2 OS Mitochondria Intensity
HPA054448 U-251 MG Mitochondria Intensity

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000022742 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA054448 NIH 3T3 No staining

GENE INFORMATION

Gene name

 CPOX (HGNC Symbol)

Synonyms

 CPO, CPX, HCP

Description

 Coproporphyrinogen oxidase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009]

Chromosome

 3

Cytoband

 q11.2

Chromosome location (bp)

 98521132 - 98593723

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080819 (version 83.38)

Entrez gene

 1371

UniProt

 P36551 (UniProt - Evidence at protein level)

neXtProt

 NX_P36551

Antibodypedia

 CPOX antibodies

PROTEIN BROWSER
CPOX-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPOX-001
ENSP00000264193
ENST00000264193
P36551 [Direct mapping]
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004109 [coproporphyrinogen oxidase activity]
GO:0005212 [structural constituent of eye lens]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006779 [porphyrin-containing compound biosynthetic process]
GO:0006782 [protoporphyrinogen IX biosynthetic process]
GO:0006783 [heme biosynthetic process]
GO:0010035 [response to inorganic substance]
GO:0010039 [response to iron ion]
GO:0010288 [response to lead ion]
GO:0016020 [membrane]
GO:0017085 [response to insecticide]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046685 [response to arsenic-containing substance]
GO:0051597 [response to methylmercury]
GO:0055114 [oxidation-reduction process]
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 454 aa
50.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.