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HSP90AA1

GENERAL INFORMATION

Gene name

 HSP90AA1

Gene description

 Heat shock protein 90kDa alpha (cytosolic), class A member 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB002058
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin02004006008001,0001,200TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0100200300400500RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina01,0002,0003,0004,0005,0006,0007,000Tags Per Million

GENE INFORMATION

Gene name

 HSP90AA1 (HGNC Symbol)

Synonyms

 FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA

Description

 Heat shock protein 90kDa alpha (cytosolic), class A member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 14

Cytoband

 q32.31

Chromosome location (bp)

 102080738 - 102139699

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080824 (version 83.38)

Entrez gene

 3320

UniProt

 P07900 (UniProt - Evidence at protein level)

neXtProt

 NX_P07900

Antibodypedia

 HSP90AA1 antibodies

PROTEIN BROWSER
HSP90AA1-001
HSP90AA1-002
HSP90AA1-005
HSP90AA1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSP90AA1-001
ENSP00000335153
ENST00000334701
P07900 [Direct mapping]
Heat shock protein HSP 90-alpha
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006839 [mitochondrial transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0032587 [ruffle membrane]
GO:0034605 [cellular response to heat]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043202 [lysosomal lumen]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045040 [protein import into mitochondrial outer membrane]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046209 [nitric oxide metabolic process]
GO:0046677 [response to antibiotic]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051020 [GTPase binding]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
GO:1900034 [regulation of cellular response to heat]
Show all
 854 aa
98.2 kDa 		No 0
HSP90AA1-002
ENSP00000216281
ENST00000216281
P07900 [Direct mapping]
Heat shock protein HSP 90-alpha
K9JA46 [Target identity:100%; Query identity:100%]
Epididymis luminal secretory protein 52; Heat shock protein 90kDa alpha (Cytosolic), class A member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006839 [mitochondrial transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0006996 [organelle organization]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0034605 [cellular response to heat]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045040 [protein import into mitochondrial outer membrane]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0046209 [nitric oxide metabolic process]
GO:0046677 [response to antibiotic]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051020 [GTPase binding]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
GO:1900034 [regulation of cellular response to heat]
Show all
 732 aa
84.7 kDa 		No 0
HSP90AA1-005
ENSP00000450712
ENST00000553585
G3V2J8 [Direct mapping]
Heat shock protein HSP 90-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0051082 [unfolded protein binding]
Show all
 174 aa
20.2 kDa 		No 0
HSP90AA1-010
ENSP00000489370
ENST00000558600
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 100 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.