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TCF7

GENERAL INFORMATION

Gene name

 TCF7

Gene description

 Transcription factor 7 (T-cell specific, HMG-box)

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Mixed
FANTOM5:Tissue enhanced (tonsil, lymph node, appendix)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in a subset of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB019403
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil, lymph node, appendix)

GENE INFORMATION

Gene name

 TCF7 (HGNC Symbol)

Synonyms

 TCF-1

Description

 Transcription factor 7 (T-cell specific, HMG-box) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 134114711 - 134151865

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000081059 (version 83.38)

Entrez gene

 6932

UniProt

 P36402 (UniProt - Evidence at protein level)

neXtProt

 NX_P36402

Antibodypedia

 TCF7 antibodies

PROTEIN BROWSER
«
TCF7-001
TCF7-002
TCF7-003
TCF7-004
TCF7-006
TCF7-009
TCF7-010
TCF7-011
TCF7-012
TCF7-014
TCF7-015
TCF7-022
TCF7-023
TCF7-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCF7-001
ENSP00000340347
ENST00000342854
P36402 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001047 [core promoter binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005719 [nuclear euchromatin]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0021915 [neural tube development]
GO:0030538 [embryonic genitalia morphogenesis]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0042127 [regulation of cell proliferation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048619 [embryonic hindgut morphogenesis]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071353 [cellular response to interleukin-4]
Show all
 384 aa
41.6 kDa 		No 0
TCF7-002
ENSP00000378472
ENST00000395029
B7WNT5 [Direct mapping]
Transcription factor 7; Transcription factor 7 (T-cell specific, HMG-box), isoform CRA_c
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 481 aa
52 kDa 		No 0
TCF7-003
ENSP00000378469
ENST00000395023
P36402 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008013 [beta-catenin binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071353 [cellular response to interleukin-4]
Show all
 269 aa
30.2 kDa 		No 0
TCF7-004
ENSP00000367822
ENST00000378560
P36402 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008013 [beta-catenin binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071353 [cellular response to interleukin-4]
Show all
 268 aa
30.3 kDa 		No 0
TCF7-006
ENSP00000430179
ENST00000518915
P36402 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008013 [beta-catenin binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071353 [cellular response to interleukin-4]
Show all
 269 aa
30.3 kDa 		No 0
TCF7-009
ENSP00000427968
ENST00000517799
H0YAR8 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 147 aa
16.8 kDa 		No 0
TCF7-010
ENSP00000430617
ENST00000518887
E5RJ51 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 123 aa
13.3 kDa 		No 0
TCF7-011
ENSP00000429946
ENST00000517851
E5RGQ1 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 168 aa
18.2 kDa 		No 0
TCF7-012
ENSP00000427782
ENST00000521639
E5RG75 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 147 aa
16 kDa 		No 0
TCF7-014
ENSP00000429696
ENST00000519037
E5RHL1 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 143 aa
15.7 kDa 		No 0
TCF7-015
ENSP00000427870
ENST00000522375
E5RG34 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 153 aa
16.5 kDa 		No 0
TCF7-022
ENSP00000429935
ENST00000520699
H0YBP2 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 105 aa
12.6 kDa 		No 0
TCF7-023
ENSP00000429178
ENST00000517855
H0YBC8 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 204 aa
22.7 kDa 		No 0
TCF7-024
ENSP00000429547
ENST00000520958
P36402 [Direct mapping]
Transcription factor 7
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0008013 [beta-catenin binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0048699 [generation of neurons]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071353 [cellular response to interleukin-4]
Show all
 269 aa
30.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.