Cell atlas - CADPS2 - The Human Protein Atlas

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CADPS2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	CADPS2
Gene description	Ca++-dependent secretion activator 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (Karpas-707, HUVEC TERT2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain), Vesicles (supported)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056398
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (uncertain), Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056398	Hep G2	Nucleoplasm
	HPA056398	Hep G2	Vesicles
	HPA056398	MCF7	Nucleoplasm
	HPA056398	U-2 OS	No staining

GENE INFORMATION
Gene name	CADPS2
Synonyms
Description	Ca++-dependent secretion activator 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Chromosome	7
Cytoband	q31.32
Chromosome location (bp)	122318425 - 122886759
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081803 (version 83.38)
Entrez gene	93664
UniProt	Q86UW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UW7
Antibodypedia	CADPS2 antibodies

PROTEIN BROWSER

CADPS2-001	CADPS2-002	CADPS2-003	CADPS2-004	CADPS2-201	CADPS2-202	CADPS2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CADPS2-001 ENSP00000398481 ENST00000449022	Q86UW7 [Direct mapping] Calcium-dependent secretion activator 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006887 [exocytosis] GO:0008289 [lipid binding] GO:0009267 [cellular response to starvation] GO:0015031 [protein transport] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016082 [synaptic vesicle priming] GO:0030054 [cell junction] GO:0030659 [cytoplasmic vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0042734 [presynaptic membrane] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045921 [positive regulation of exocytosis] GO:0046872 [metal ion binding] Show all	1296 aa 147.7 kDa	No	0
CADPS2-002 ENSP00000400401 ENST00000412584	Q86UW7 [Direct mapping] Calcium-dependent secretion activator 2 X5DNG0 [Target identity:100%; Query identity:100%] Ca++-dependent secretion activator 2 isoform D Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006887 [exocytosis] GO:0008289 [lipid binding] GO:0015031 [protein transport] GO:0030054 [cell junction] GO:0030659 [cytoplasmic vesicle membrane] GO:0045202 [synapse] GO:0046872 [metal ion binding] Show all	1255 aa 143.5 kDa	No	0
CADPS2-003 ENSP00000380833 ENST00000397721	H7BYR4 [Direct mapping] Calcium-dependent secretion activator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	899 aa 103 kDa	No	0
CADPS2-004 ENSP00000419418 ENST00000462699	H0Y8B5 [Direct mapping] Calcium-dependent secretion activator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		490 aa 56.1 kDa	No	0
CADPS2-201 ENSP00000325581 ENST00000313070	F8W8P5 [Direct mapping] Calcium-dependent secretion activator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1194 aa 136.6 kDa	No	0
CADPS2-202 ENSP00000333940 ENST00000334010	C9IYE1 [Direct mapping] Calcium-dependent secretion activator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1294 aa 147.6 kDa	No	0
CADPS2-203 ENSP00000484355 ENST00000615869	A0A087X1P3 [Direct mapping] Calcium-dependent secretion activator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1301 aa 148.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.