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ATP8B1

CANCER ATLAS

Gene description

 ATPase, aminophospholipid transporter, class I, type 8B, member 1

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018673
HPA018674

GENE INFORMATION

Gene name

 ATP8B1 (HGNC Symbol)

Synonyms

 ATPIC, BRIC, FIC1, PFIC, PFIC1

Description

 ATPase, aminophospholipid transporter, class I, type 8B, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q21.31

Chromosome location (bp)

 57646426 - 57803101

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000081923 (version 83.38)

Entrez gene

 5205

UniProt

 O43520 (UniProt - Evidence at protein level)

neXtProt

 NX_O43520

Antibodypedia

 ATP8B1 antibodies

PROTEIN BROWSER
ATP8B1-001
ATP8B1-003
ATP8B1-006
ATP8B1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP8B1-001
ENSP00000283684
ENST00000283684
O43520 [Direct mapping]
Phospholipid-transporting ATPase IC
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006855 [drug transmembrane transport]
GO:0007030 [Golgi organization]
GO:0015721 [bile acid and bile salt transport]
GO:0015914 [phospholipid transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0032420 [stereocilium]
GO:0032534 [regulation of microvillus assembly]
GO:0034220 [ion transmembrane transport]
GO:0045332 [phospholipid translocation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
Show all
 1251 aa
143.7 kDa 		No >9
ATP8B1-003
ENSP00000468266
ENST00000588255
K7ERI0 [Direct mapping]
Phospholipid-transporting ATPase IC
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0007030 [Golgi organization]
GO:0016021 [integral component of membrane]
GO:0045332 [phospholipid translocation]
Show all
 92 aa
10.8 kDa 		No 0
ATP8B1-006
ENSP00000468751
ENST00000585322
K7ESK2 [Direct mapping]
Phospholipid-transporting ATPase IC
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007030 [Golgi organization]
Show all
 11 aa
1.3 kDa 		No 0
ATP8B1-201
ENSP00000445359
ENST00000536015
O43520 [Direct mapping]
Phospholipid-transporting ATPase IC
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006855 [drug transmembrane transport]
GO:0007030 [Golgi organization]
GO:0007605 [sensory perception of sound]
GO:0008206 [bile acid metabolic process]
GO:0015721 [bile acid and bile salt transport]
GO:0015914 [phospholipid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0021650 [vestibulocochlear nerve formation]
GO:0031526 [brush border membrane]
GO:0032420 [stereocilium]
GO:0032534 [regulation of microvillus assembly]
GO:0034220 [ion transmembrane transport]
GO:0045332 [phospholipid translocation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0060119 [inner ear receptor cell development]
GO:1901612 [cardiolipin binding]
Show all
 1251 aa
143.7 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.