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Weak to moderate cytoplasmic, membranous and rare nuclear positivity was seen in malignant tissues. Most malignant lymphomas and several colorectal cancers were strongly stained.
Weak to moderate cytoplasmic and occasional membranous positivity was seen in most malignant cells. Cervical and most skin cancers were negative.
GENE INFORMATION
Gene name
ATP8B1 (HGNC Symbol)
Synonyms
ATPIC, BRIC, FIC1, PFIC, PFIC1
Description
ATPase, aminophospholipid transporter, class I, type 8B, member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008]