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FYB

CANCER ATLAS

Gene description

 FYN binding protein

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA026796
CAB025336

GENE INFORMATION

Gene name

 FYB (HGNC Symbol)

Synonyms

 FYB-120/130, SLAP-130

Description

 FYN binding protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

 5

Cytoband

 p13.1

Chromosome location (bp)

 39105236 - 39274528

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082074 (version 83.38)

Entrez gene

 2533

UniProt

 O15117 (UniProt - Evidence at protein level)

neXtProt

 NX_O15117

Antibodypedia

 FYB antibodies

PROTEIN BROWSER
FYB-001
FYB-002
FYB-003
FYB-004
FYB-005
FYB-006
FYB-007
FYB-009
FYB-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FYB-001
ENSP00000316460
ENST00000351578
O15117 [Direct mapping]
FYN-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008150 [biological_process]
GO:0015629 [actin cytoskeleton]
GO:0035556 [intracellular signal transduction]
GO:0050852 [T cell receptor signaling pathway]
Show all
 783 aa
85.4 kDa 		No 0
FYB-002
ENSP00000426346
ENST00000515010
O15117 [Direct mapping]
FYN-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008150 [biological_process]
GO:0015629 [actin cytoskeleton]
GO:0035556 [intracellular signal transduction]
GO:0050852 [T cell receptor signaling pathway]
Show all
 783 aa
85.4 kDa 		No 0
FYB-003
ENSP00000425845
ENST00000512982
O15117 [Direct mapping]
FYN-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008150 [biological_process]
GO:0015629 [actin cytoskeleton]
GO:0032403 [protein complex binding]
GO:0035556 [intracellular signal transduction]
GO:0050852 [T cell receptor signaling pathway]
GO:0072659 [protein localization to plasma membrane]
Show all
 839 aa
91.7 kDa 		No 0
FYB-004
ENSP00000427114
ENST00000505428
O15117 [Direct mapping]
FYN-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008150 [biological_process]
GO:0015629 [actin cytoskeleton]
GO:0035556 [intracellular signal transduction]
GO:0050852 [T cell receptor signaling pathway]
Show all
 829 aa
90.6 kDa 		No 0
FYB-005
ENSP00000421988
ENST00000506557
D6RAE8 [Direct mapping]
FYN-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 62 aa
6.4 kDa 		No 0
FYB-006
ENSP00000423888
ENST00000509072
D6RC38 [Direct mapping]
FYN-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 22 aa
2.4 kDa 		No 0
FYB-007
ENSP00000420989
ENST00000504542
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 2 aa
0.2 kDa 		No 0
FYB-009
ENSP00000424919
ENST00000512138
D6RER7 [Direct mapping]
FYN-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 115 aa
12 kDa 		No 0
FYB-010
ENSP00000426597
ENST00000510188
D6RFJ5 [Direct mapping]
FYN-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 174 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.