Fields »
ABOUT
HELP
BLOG
MPP4

GENERAL INFORMATION

Gene name

 MPP4

Gene description

 Membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis, skin)
GTEx:Tissue enhanced (cerebellum, spleen)
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 MPP4 (HGNC Symbol)

Synonyms

 DLG6

Description

 Membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 201644870 - 201698694

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082126 (version 83.38)

Entrez gene

 58538

UniProt

 Q96JB8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96JB8

Antibodypedia

 MPP4 antibodies

PROTEIN BROWSER
MPP4-001
MPP4-002
MPP4-007
MPP4-008
MPP4-009
MPP4-010
MPP4-012
MPP4-201
MPP4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MPP4-001
ENSP00000387278
ENST00000409474
Q96JB8 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0035418 [protein localization to synapse]
GO:0042734 [presynaptic membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 637 aa
72.8 kDa 		No 0
MPP4-002
ENSP00000319363
ENST00000315506
Q96JB8 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 593 aa
67.6 kDa 		No 0
MPP4-007
ENSP00000387293
ENST00000409143
F6Q0Y6 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 579 aa
66 kDa 		No 0
MPP4-008
ENSP00000380095
ENST00000396886
E9PG92 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 562 aa
64.3 kDa 		No 0
MPP4-009
ENSP00000416781
ENST00000428900
E7ET46 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 613 aa
70.1 kDa 		No 0
MPP4-010
ENSP00000406160
ENST00000447335
E7EUL8 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 630 aa
71.9 kDa 		No 0
MPP4-012
ENSP00000473500
ENST00000602867
R4GN59 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 171 aa
19.3 kDa 		No 0
MPP4-201
ENSP00000353047
ENST00000359962
E7EUL8 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 630 aa
71.9 kDa 		No 0
MPP4-202
ENSP00000478875
ENST00000620095
A0A087WUS1 [Direct mapping]
MAGUK p55 subfamily member 4
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 606 aa
69.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.