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A few cases of colorectal cancers showed moderate to strong cytoplasmic staining while a few cases of endometrial cancers showed weak to moderate staining. Remaining cancer tissues were negative or weakly stained.
Strong cytoplasmic positivity was observed in thyroid cancers. A few cases of endometrial, ovarian and skin cancers showed weak to moderate cytoplasmic immunoreactivity. The remaining cancer tissues were mainly negative.
GENE INFORMATION
Gene name
STRADB (HGNC Symbol)
Synonyms
ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK
Description
STE20-related kinase adaptor beta (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Enzymes Kinases STE Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000902 [cell morphogenesis] GO:0004672 [protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006611 [protein export from nucleus] GO:0007050 [cell cycle arrest] GO:0007254 [JNK cascade] GO:0007266 [Rho protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008286 [insulin receptor signaling pathway] GO:0016477 [cell migration] GO:0023014 [signal transduction by protein phosphorylation] GO:0030036 [actin cytoskeleton organization] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] GO:0043408 [regulation of MAPK cascade] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Q9C0K7 [Direct mapping] STE20-related kinase adapter protein beta
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Enzymes Kinases STE Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
