Expression of KCNK2 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, two pore domain subfamily K, member 2

Protein class

FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA056054

GENE INFORMATION
Gene name	KCNK2 (HGNC Symbol)
Synonyms	K2p2.1, TREK-1
Description	Potassium channel, two pore domain subfamily K, member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q41
Chromosome location (bp)	215005775 - 215237093
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000082482 (version 83.38)
Entrez gene	3776
UniProt	O95069 (UniProt - Evidence at protein level)
neXtProt	NX_O95069
Antibodypedia	KCNK2 antibodies

PROTEIN BROWSER

KCNK2-001	KCNK2-002	KCNK2-003	KCNK2-008	KCNK2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK2-001 ENSP00000394033 ENST00000444842	O95069 [Direct mapping] Potassium channel subfamily K member 2 Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003231 [cardiac ventricle development] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007613 [memory] GO:0008076 [voltage-gated potassium channel complex] GO:0009612 [response to mechanical stimulus] GO:0009986 [cell surface] GO:0010942 [positive regulation of cell death] GO:0015271 [outward rectifier potassium channel activity] GO:0016324 [apical plasma membrane] GO:0019870 [potassium channel inhibitor activity] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0030424 [axon] GO:0042391 [regulation of membrane potential] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043679 [axon terminus] GO:0044305 [calyx of Held] GO:0048678 [response to axon injury] GO:0060044 [negative regulation of cardiac muscle cell proliferation] GO:0071456 [cellular response to hypoxia] GO:0071805 [potassium ion transmembrane transport] GO:0090102 [cochlea development] GO:0097449 [astrocyte projection] GO:1900039 [positive regulation of cellular response to hypoxia] GO:2000279 [negative regulation of DNA biosynthetic process] Show all	426 aa 47.1 kDa	No	6
KCNK2-002 ENSP00000375764 ENST00000391894	O95069 [Direct mapping] Potassium channel subfamily K member 2 U3N6F0 [Target identity:100%; Query identity:100%] Potassium channel subfamily k member 2 variant 2 Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007268 [synaptic transmission] GO:0015271 [outward rectifier potassium channel activity] GO:0019870 [potassium channel inhibitor activity] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	411 aa 45.5 kDa	No	6
KCNK2-003 ENSP00000413460 ENST00000457122	C9JXY2 [Direct mapping] Potassium channel subfamily K member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0015271 [outward rectifier potassium channel activity] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	125 aa 13.7 kDa	No	2
KCNK2-008 ENSP00000375765 ENST00000391895	O95069 [Direct mapping] Potassium channel subfamily K member 2 U3N834 [Target identity:100%; Query identity:100%] Potassium channel subfamily k member 2 variant 1 Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007268 [synaptic transmission] GO:0015271 [outward rectifier potassium channel activity] GO:0019870 [potassium channel inhibitor activity] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	422 aa 46.9 kDa	No	6
KCNK2-011 ENSP00000420569 ENST00000478774	C9JDK1 [Direct mapping] Potassium channel subfamily K member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0015271 [outward rectifier potassium channel activity] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	118 aa 12.9 kDa	No	2