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ERC1

CANCER ATLAS

Gene description

 ELKS/RAB6-interacting/CAST family member 1

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019513
HPA019523
HPA024130

GENE INFORMATION

Gene name

 ERC1 (HGNC Symbol)

Synonyms

 CAST2, ELKS, KIAA1081, MGC12974, RAB6IP2

Description

 ELKS/RAB6-interacting/CAST family member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 990509 - 1495933

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082805 (version 83.38)

Entrez gene

 23085

UniProt

 Q8IUD2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IUD2

Antibodypedia

 ERC1 antibodies

PROTEIN BROWSER
«
ERC1-001
ERC1-005
ERC1-006
ERC1-011
ERC1-014
ERC1-015
ERC1-020
ERC1-023
ERC1-201
ERC1-202
ERC1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERC1-001
ENSP00000438546
ENST00000543086
Q8IUD2 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007252 [I-kappaB phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0008385 [IkappaB kinase complex]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042734 [presynaptic membrane]
GO:0043522 [leucine zipper domain binding]
GO:0045202 [synapse]
GO:0048786 [presynaptic active zone]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 1088 aa
124.9 kDa 		No 0
ERC1-005
ENSP00000465628
ENST00000545318
K7EKH8 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 90 aa
9.3 kDa 		No 0
ERC1-006
ENSP00000467476
ENST00000592048
K7EPP6 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0048786 [presynaptic active zone]
Show all
 344 aa
40.6 kDa 		No 0
ERC1-011
ENSP00000347621
ENST00000355446
G8JLD3 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0048786 [presynaptic active zone]
Show all
 1086 aa
124.8 kDa 		No 0
ERC1-014
ENSP00000354158
ENST00000360905
Q8IUD2 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007252 [I-kappaB phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0008385 [IkappaB kinase complex]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042734 [presynaptic membrane]
GO:0043522 [leucine zipper domain binding]
GO:0045202 [synapse]
GO:0048786 [presynaptic active zone]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 1116 aa
128.1 kDa 		No 0
ERC1-015
ENSP00000442739
ENST00000546231
X6RLX0 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0048786 [presynaptic active zone]
Show all
 1120 aa
128.5 kDa 		No 0
ERC1-020
ENSP00000467196
ENST00000539802
K7EP25 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 89 aa
10.1 kDa 		No 0
ERC1-023
ENSP00000464959
ENST00000589132
K7EIZ7 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 145 aa
14.9 kDa 		No 0
ERC1-201
ENSP00000380386
ENST00000397203
Q8IUD2 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007252 [I-kappaB phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0008385 [IkappaB kinase complex]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042734 [presynaptic membrane]
GO:0043522 [leucine zipper domain binding]
GO:0045202 [synapse]
GO:0048786 [presynaptic active zone]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 1088 aa
124.9 kDa 		No 0
ERC1-202
ENSP00000468263
ENST00000589028
Q8IUD2 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007252 [I-kappaB phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0008385 [IkappaB kinase complex]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042734 [presynaptic membrane]
GO:0043522 [leucine zipper domain binding]
GO:0045202 [synapse]
GO:0048786 [presynaptic active zone]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 1116 aa
128.1 kDa 		No 0
ERC1-203
ENSP00000479523
ENST00000611180
Q8IUD2 [Direct mapping]
ELKS/Rab6-interacting/CAST family member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007252 [I-kappaB phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0008385 [IkappaB kinase complex]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042734 [presynaptic membrane]
GO:0043522 [leucine zipper domain binding]
GO:0045202 [synapse]
GO:0048786 [presynaptic active zone]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 720 aa
82 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.