Expression of PALB2 in cancer - Summary

CANCER ATLAS

Gene description

Partner and localizer of BRCA2

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB014895

GENE INFORMATION
Gene name	PALB2 (HGNC Symbol)
Synonyms	FANCN, FLJ21816
Description	Partner and localizer of BRCA2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p12.2
Chromosome location (bp)	23603160 - 23641310
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000083093 (version 83.38)
Entrez gene	79728
UniProt	Q86YC2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YC2
Antibodypedia	PALB2 antibodies

PROTEIN BROWSER

PALB2-001	PALB2-002	PALB2-005	PALB2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PALB2-001 ENSP00000261584 ENST00000261584	Q86YC2 [Direct mapping] Partner and localizer of BRCA2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0001701 [in utero embryonic development] GO:0001756 [somitogenesis] GO:0001833 [inner cell mass cell proliferation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0007498 [mesoderm development] GO:0009887 [organ morphogenesis] GO:0031052 [chromosome breakage] GO:0035264 [multicellular organism growth] GO:0036342 [post-anal tail morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0045003 [double-strand break repair via synthesis-dependent strand annealing] GO:0048568 [embryonic organ development] Show all	1186 aa 131.3 kDa	No	0
PALB2-002 ENSP00000454703 ENST00000568219	H3BN63 [Direct mapping] Partner and localizer of BRCA2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	891 aa 98 kDa	No	0
PALB2-005 ENSP00000459237 ENST00000566069	I3L1Z5 [Direct mapping] Partner and localizer of BRCA2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.8 kDa	No	0
PALB2-006 ENSP00000460666 ENST00000561514	I3L3R6 [Direct mapping] Partner and localizer of BRCA2 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.5 kDa	No	0