Expression of PLOD1 in cancer - Summary

CANCER ATLAS

Gene description

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049137	HPA055799

GENE INFORMATION
Gene name	PLOD1 (HGNC Symbol)
Synonyms	LH1, LLH, PLOD
Description	Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (HGNC Symbol)
Entrez gene summary	Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	11934205 - 11975538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000083444 (version 83.38)
Entrez gene	5351
UniProt	Q02809 (UniProt - Evidence at protein level)
neXtProt	NX_Q02809
Antibodypedia	PLOD1 antibodies

PROTEIN BROWSER

PLOD1-001	PLOD1-003	PLOD1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLOD1-001 ENSP00000196061 ENST00000196061	Q02809 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 A0A024R4H0 [Target identity:100%; Query identity:100%] Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0005506 [iron ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006464 [cellular protein modification process] GO:0008198 [ferrous iron binding] GO:0008475 [procollagen-lysine 5-dioxygenase activity] GO:0008544 [epidermis development] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0017185 [peptidyl-lysine hydroxylation] GO:0030198 [extracellular matrix organization] GO:0030867 [rough endoplasmic reticulum membrane] GO:0031418 [L-ascorbic acid binding] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0042803 [protein homodimerization activity] GO:0046947 [hydroxylysine biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	727 aa 83.5 kDa	Yes	0
PLOD1-003 ENSP00000405372 ENST00000429000	Q5JXB7 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		283 aa 31.7 kDa	Yes	0
PLOD1-005 ENSP00000414443 ENST00000449038	Q5JXB8 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		225 aa 24.6 kDa	Yes	0