Expression of DIS3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039281

GENE INFORMATION
Gene name	DIS3 (HGNC Symbol)
Synonyms	dis3p, EXOSC11, KIAA1008, RRP44
Description	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q21.33
Chromosome location (bp)	72752169 - 72782096
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000083520 (version 83.38)
Entrez gene	22894
UniProt	Q9Y2L1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2L1
Antibodypedia	DIS3 antibodies

PROTEIN BROWSER

DIS3-001	DIS3-002	DIS3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DIS3-001 ENSP00000366997 ENST00000377767	Q9Y2L1 [Direct mapping] Exosome complex exonuclease RRP44 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0000176 [nuclear exosome (RNase complex)] GO:0000177 [cytoplasmic exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0003723 [RNA binding] GO:0004519 [endonuclease activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006364 [rRNA processing] GO:0006402 [mRNA catabolic process] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016075 [rRNA catabolic process] GO:0043488 [regulation of mRNA stability] GO:0043547 [positive regulation of GTPase activity] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0071034 [CUT catabolic process] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	958 aa 109 kDa	No	0
DIS3-002 ENSP00000367011 ENST00000377780	Q9Y2L1 [Direct mapping] Exosome complex exonuclease RRP44 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0000176 [nuclear exosome (RNase complex)] GO:0000177 [cytoplasmic exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0003723 [RNA binding] GO:0004519 [endonuclease activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006364 [rRNA processing] GO:0006402 [mRNA catabolic process] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016075 [rRNA catabolic process] GO:0043488 [regulation of mRNA stability] GO:0043547 [positive regulation of GTPase activity] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0071034 [CUT catabolic process] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	928 aa 105 kDa	No	0
DIS3-201 ENSP00000440058 ENST00000545453	G3V1J5 [Direct mapping] Exosome complex exonuclease RRP44; KIAA1008, isoform CRA_c Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000177 [cytoplasmic exosome (RNase complex)] GO:0006402 [mRNA catabolic process] Show all	796 aa 90.6 kDa	No	0