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NUFIP1

GENERAL INFORMATION

Gene name

 NUFIP1

Gene description

 Nuclear fragile X mental retardation protein interacting protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA029958
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NUFIP1 (HGNC Symbol)

Synonyms

 NUFIP

Description

 Nuclear fragile X mental retardation protein interacting protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012]

Chromosome

 13

Cytoband

 q14.12

Chromosome location (bp)

 44939249 - 44989483

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000083635 (version 83.38)

Entrez gene

 26747

UniProt

 Q9UHK0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHK0

Antibodypedia

 NUFIP1 antibodies

PROTEIN BROWSER
NUFIP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUFIP1-001
ENSP00000368459
ENST00000379161
Q9UHK0 [Direct mapping]
Nuclear fragile X mental retardation-interacting protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000492 [box C/D snoRNP assembly]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005726 [perichromatin fibrils]
GO:0005730 [nucleolus]
GO:0006396 [RNA processing]
GO:0008023 [transcription elongation factor complex]
GO:0016363 [nuclear matrix]
GO:0022626 [cytosolic ribosome]
GO:0030515 [snoRNA binding]
GO:0030674 [protein binding, bridging]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048786 [presynaptic active zone]
GO:0070761 [pre-snoRNP complex]
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 495 aa
56.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.