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Cancer tissues showed moderate nuclear/nucleolar and cytoplasmic positivity. A few cases of malignant gliomas, melanomas, gastric, endometrial and breast cancers displayed strong positivity.
GENE INFORMATION
Gene name
PDS5B (HGNC Symbol)
Synonyms
APRIN, AS3, CG008, FLJ23236, KIAA0979
Description
PDS5 cohesin associated factor B (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]