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Most tumors displayed weak to moderate cytoplasmic immunoreactivity. Focal strong cytoplasmic staining, in some cases with a granular pattern, was observed in a few endometrial-, lung- and liver cancers.
A majority of malignant cells showed weak to moderate cytoplasmic staining. Malignant lymphomas, lung and breast cancer were mostly negative.
GENE INFORMATION
Gene name
FAT1 (HGNC Symbol)
Synonyms
CDHF7, CDHR8, FAT
Description
FAT atypical cadherin 1 (HGNC Symbol)
Entrez gene summary
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]