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Most malignant tissues showed weak to moderate cytoplasmic immunoreactivity with additional membranous staining in a few cases. Testicular cancers as well as most urothelial cancer and malignant gliomas were negative.
Cancers generally displayed moderate cytoplasmic positivity with additional membranous staining in several cases. Renal cancers showed additional nuclear positivity. A few cases of colorectal, lung and renal cancers were strongly stained. Several urothelial cancers, squamous and basal cell carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
HAL (HGNC Symbol)
Synonyms
HIS
Description
Histidine ammonia-lyase (HGNC Symbol)
Entrez gene summary
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity] GO:0004397 [histidine ammonia-lyase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006548 [histidine catabolic process] GO:0016841 [ammonia-lyase activity] GO:0019556 [histidine catabolic process to glutamate and formamide] GO:0019557 [histidine catabolic process to glutamate and formate] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process]
Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004397 [histidine ammonia-lyase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006548 [histidine catabolic process] GO:0016841 [ammonia-lyase activity] GO:0019556 [histidine catabolic process to glutamate and formamide] GO:0019557 [histidine catabolic process to glutamate and formate] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process]
Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004397 [histidine ammonia-lyase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006548 [histidine catabolic process] GO:0016841 [ammonia-lyase activity] GO:0019556 [histidine catabolic process to glutamate and formamide] GO:0019557 [histidine catabolic process to glutamate and formate] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process]
