Tissue expression of SLCO1A2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLCO1A2
Gene description	Solute carrier organic anion transporter family, member 1A2
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Group enriched (hippocampus, hypothalamus, caudate, cerebral cortex)
FANTOM5:	Tissue enhanced (brain, hippocampus, caudate)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, hypothalamus, caudate, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, hippocampus, caudate)

GENE INFORMATION
Gene name	SLCO1A2 (HGNC Symbol)
Synonyms	OATP, OATP-A, OATP1A2, SLC21A3
Description	Solute carrier organic anion transporter family, member 1A2 (HGNC Symbol)
Entrez gene summary	This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	21264600 - 21419594
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000084453 (version 83.38)
Entrez gene	6579
UniProt	P46721 (UniProt - Evidence at transcript level)
neXtProt	NX_P46721
Antibodypedia	SLCO1A2 antibodies

PROTEIN BROWSER

SLCO1A2-001	SLCO1A2-002	SLCO1A2-005	SLCO1A2-007	SLCO1A2-008	SLCO1A2-009	SLCO1A2-010	SLCO1A2-011	SLCO1A2-012	SLCO1A2-013	SLCO1A2-014	SLCO1A2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLCO1A2-001 ENSP00000305974 ENST00000307378	P46721 [Direct mapping] Solute carrier organic anion transporter family member 1A2 A0A024RAT5 [Target identity:100%; Query identity:100%] Solute carrier organic anion transporter family member Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0043252 [sodium-independent organic anion transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	670 aa 74.1 kDa	No	>9
SLCO1A2-002 ENSP00000394854 ENST00000458504	B4DJE6 [Direct mapping] Solute carrier organic anion transporter family member Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	538 aa 59.4 kDa	No	8
SLCO1A2-005 ENSP00000409691 ENST00000445053	C9JSB7 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] Show all	71 aa 8 kDa	Yes	0
SLCO1A2-007 ENSP00000401195 ENST00000435179	C9K059 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	88 aa 10 kDa	No	1
SLCO1A2-008 ENSP00000403638 ENST00000413682	C9JCA7 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	Predicted intracellular proteins Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] Show all	32 aa 3.7 kDa	No	0
SLCO1A2-009 ENSP00000409314 ENST00000453443	C9JTF6 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	137 aa 15.3 kDa	No	2
SLCO1A2-010 ENSP00000407462 ENST00000450590	C9JUW6 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	91 aa 10.3 kDa	No	1
SLCO1A2-011 ENSP00000390572 ENST00000421294	C9JGK7 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	99 aa 11 kDa	No	1
SLCO1A2-012 ENSP00000416190 ENST00000422327	C9JHU9 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	147 aa 16.4 kDa	No	2
SLCO1A2-013 ENSP00000390672 ENST00000421287	C9JG34 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	51 aa 5.9 kDa	No	0
SLCO1A2-014 ENSP00000410338 ENST00000430803		Predicted intracellular proteins Show all		2 aa 0.2 kDa	No	0
SLCO1A2-015 ENSP00000392124 ENST00000416627	C9IYW8 [Direct mapping] Solute carrier organic anion transporter family member 1A2 Show all	Predicted intracellular proteins Show all		13 aa 1.6 kDa	No	0