Cell atlas - GCKR - The Human Protein Atlas

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GCKR

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments

Human cell
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	GCKR
Gene description	Glucokinase (hexokinase 4) regulator
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the intermediate filaments.
RNA cell category	Group enriched (Hep G2, HEL, HUVEC TERT2, TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA064305
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, HEL, HUVEC TERT2, TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the intermediate filaments.

Main location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064305	HUVEC TERT2	No staining
	HPA064305	Hep G2	Intermediate filaments	Spatial
	HPA064305	U-2 OS	No staining

GENE INFORMATION
Gene name	GCKR
Synonyms
Description	Glucokinase (hexokinase 4) regulator (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27496842 - 27523684
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000084734 (version 83.38)
Entrez gene	2646
UniProt
neXtProt
Antibodypedia	GCKR antibodies

PROTEIN BROWSER

GCKR-001	GCKR-004	GCKR-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCKR-001 ENSP00000264717 ENST00000264717	A0A0C4DFN2 [Direct mapping] Glucokinase (Hexokinase 4) regulator; Glucokinase regulatory protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000060 [protein import into nucleus, translocation] GO:0001678 [cellular glucose homeostasis] GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0009750 [response to fructose] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030246 [carbohydrate binding] GO:0033132 [negative regulation of glucokinase activity] GO:0033133 [positive regulation of glucokinase activity] GO:0034504 [protein localization to nucleus] GO:0043086 [negative regulation of catalytic activity] Show all	625 aa 68.7 kDa	No	0
GCKR-004 ENSP00000399463 ENST00000453813	H7C1B4 [Direct mapping] Glucokinase regulatory protein Show all	Predicted intracellular proteins Show all	GO:0005975 [carbohydrate metabolic process] GO:0030246 [carbohydrate binding] Show all	227 aa 24.4 kDa	No	0
GCKR-006 ENSP00000416917 ENST00000411584	H7C4D3 [Direct mapping] Glucokinase regulatory protein Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005975 [carbohydrate metabolic process] GO:0030246 [carbohydrate binding] Show all	189 aa 21.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.