Expression of HADHA in cancer - Summary

CANCER ATLAS

Gene description

Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015536

GENE INFORMATION
Gene name	HADHA (HGNC Symbol)
Synonyms	GBP, LCEH, LCHAD, MTPA
Description	Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (HGNC Symbol)
Entrez gene summary	This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	26190635 - 26244726
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000084754 (version 83.38)
Entrez gene	3030
UniProt	P40939 (UniProt - Evidence at protein level)
neXtProt	NX_P40939
Antibodypedia	HADHA antibodies

PROTEIN BROWSER

HADHA-001	HADHA-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HADHA-001 ENSP00000370023 ENST00000380649	P40939 [Direct mapping] Trifunctional enzyme subunit alpha, mitochondrial Long-chain enoyl-CoA hydratase Long chain 3-hydroxyacyl-CoA dehydrogenase E9KL44 [Target identity:100%; Query identity:100%] Epididymis tissue sperm binding protein Li 14m Show all	Enzymes ENZYME proteins Oxidoreductases Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003824 [catalytic activity] GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0003985 [acetyl-CoA C-acetyltransferase activity] GO:0003988 [acetyl-CoA C-acyltransferase activity] GO:0004300 [enoyl-CoA hydratase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006631 [fatty acid metabolic process] GO:0006635 [fatty acid beta-oxidation] GO:0006644 [phospholipid metabolic process] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0016507 [mitochondrial fatty acid beta-oxidation multienzyme complex] GO:0016508 [long-chain-enoyl-CoA hydratase activity] GO:0016509 [long-chain-3-hydroxyacyl-CoA dehydrogenase activity] GO:0032403 [protein complex binding] GO:0032868 [response to insulin] GO:0035965 [cardiolipin acyl-chain remodeling] GO:0042493 [response to drug] GO:0042645 [mitochondrial nucleoid] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	763 aa 83 kDa	No	0
HADHA-004 ENSP00000438039 ENST00000492433	H0YFD6 [Direct mapping] Trifunctional enzyme subunit alpha, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0006631 [fatty acid metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	250 aa 27.1 kDa	No	0