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CAD

CANCER ATLAS

Gene description

 Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Protein class

 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA069341
CAB007781

GENE INFORMATION

Gene name

 CAD

Synonyms

Description

 Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (HGNC Symbol)

Entrez gene summary

 The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 27217390 - 27243943

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000084774 (version 83.38)

Entrez gene

 790

UniProt

 P27708 (UniProt - Evidence at protein level)

neXtProt

 NX_P27708

Antibodypedia

 CAD antibodies

PROTEIN BROWSER
CAD-001
CAD-002
CAD-004
CAD-008
CAD-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAD-001
ENSP00000264705
ENST00000264705
P27708 [Direct mapping]
CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0001889 [liver development]
GO:0004070 [aspartate carbamoyltransferase activity]
GO:0004087 [carbamoyl-phosphate synthase (ammonia) activity]
GO:0004088 [carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity]
GO:0004151 [dihydroorotase activity]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006526 [arginine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0006807 [nitrogen compound metabolic process]
GO:0007507 [heart development]
GO:0007565 [female pregnancy]
GO:0007595 [lactation]
GO:0008270 [zinc ion binding]
GO:0014075 [response to amine]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0016597 [amino acid binding]
GO:0016743 [carboxyl- or carbamoyltransferase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0016812 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides]
GO:0017144 [drug metabolic process]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019899 [enzyme binding]
GO:0031000 [response to caffeine]
GO:0031100 [organ regeneration]
GO:0033574 [response to testosterone]
GO:0035690 [cellular response to drug]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043234 [protein complex]
GO:0044205 ['de novo' UMP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046134 [pyrimidine nucleoside biosynthetic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051414 [response to cortisol]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0070335 [aspartate binding]
GO:0071364 [cellular response to epidermal growth factor stimulus]
Show all
 2225 aa
243 kDa 		No 0
CAD-002
ENSP00000384510
ENST00000403525
F8VPD4 [Direct mapping]
CAD protein
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0004070 [aspartate carbamoyltransferase activity]
GO:0004087 [carbamoyl-phosphate synthase (ammonia) activity]
GO:0004088 [carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006526 [arginine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0006807 [nitrogen compound metabolic process]
GO:0016597 [amino acid binding]
GO:0016743 [carboxyl- or carbamoyltransferase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0016812 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides]
GO:0046872 [metal ion binding]
Show all
 2162 aa
236 kDa 		No 0
CAD-004
ENSP00000388740
ENST00000456311
H7BZB3 [Direct mapping]
CAD protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0004070 [aspartate carbamoyltransferase activity]
GO:0004087 [carbamoyl-phosphate synthase (ammonia) activity]
GO:0004088 [carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity]
GO:0005737 [cytoplasm]
GO:0006520 [cellular amino acid metabolic process]
GO:0006526 [arginine biosynthetic process]
GO:0016597 [amino acid binding]
GO:0016743 [carboxyl- or carbamoyltransferase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 280 aa
31.1 kDa 		No 0
CAD-008
ENSP00000414742
ENST00000458503
H7C3Z5 [Direct mapping]
CAD protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0004070 [aspartate carbamoyltransferase activity]
GO:0004087 [carbamoyl-phosphate synthase (ammonia) activity]
GO:0004088 [carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity]
GO:0005737 [cytoplasm]
GO:0006526 [arginine biosynthetic process]
GO:0016787 [hydrolase activity]
GO:0016812 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides]
GO:0046872 [metal ion binding]
Show all
 269 aa
28.9 kDa 		No 0
CAD-011
ENSP00000405416
ENST00000428460
H7C2E4 [Direct mapping]
CAD protein
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000050 [urea cycle]
GO:0004070 [aspartate carbamoyltransferase activity]
GO:0004087 [carbamoyl-phosphate synthase (ammonia) activity]
GO:0004088 [carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity]
GO:0005737 [cytoplasm]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0006520 [cellular amino acid metabolic process]
GO:0006526 [arginine biosynthetic process]
GO:0016597 [amino acid binding]
GO:0016743 [carboxyl- or carbamoyltransferase activity]
Show all
 293 aa
32.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.