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MECOM

CANCER ATLAS

Gene description

 MDS1 and EVI1 complex locus

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046537

GENE INFORMATION

Gene name

 MECOM (HGNC Symbol)

Synonyms

 EVI1, MDS1, MDS1-EVI1, PRDM3

Description

 MDS1 and EVI1 complex locus (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

 3

Cytoband

 q26.2

Chromosome location (bp)

 169083499 - 169663618

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085276 (version 83.38)

Entrez gene

 2122

UniProt

 Q03112 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03112

Antibodypedia

 MECOM antibodies

PROTEIN BROWSER
«
MECOM-004
MECOM-005
MECOM-006
MECOM-007
MECOM-008
MECOM-009
MECOM-010
MECOM-011
MECOM-012
MECOM-015
MECOM-016
MECOM-017
MECOM-018
MECOM-019
MECOM-020
MECOM-201
MECOM-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MECOM-004
ENSP00000417899
ENST00000494292
E7EQ57 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016235 [aggresome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
Show all
 1230 aa
138.1 kDa 		No 0
MECOM-005
ENSP00000419537
ENST00000486748
C9JU02 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
13.8 kDa 		No 0
MECOM-006
ENSP00000418689
ENST00000466623
Q8IU84 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1; Zinc finger transcription factor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 22 aa
2.8 kDa 		No 0
MECOM-007
ENSP00000418046
ENST00000481315
E9PGE9 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.6 kDa 		No 0
MECOM-008
ENSP00000418828
ENST00000475754
E7EU48 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 68 aa
8.1 kDa 		No 0
MECOM-009
ENSP00000420072
ENST00000494597
E7EPY2 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 103 aa
12.3 kDa 		No 0
MECOM-010
ENSP00000419757
ENST00000487503
E7EPY2 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 103 aa
12.3 kDa 		No 0
MECOM-011
ENSP00000417922
ENST00000460890
E7EPY2 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 103 aa
12.3 kDa 		No 0
MECOM-012
ENSP00000417299
ENST00000484519
E7ERX0 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 125 aa
15 kDa 		No 0
MECOM-015
ENSP00000417506
ENST00000492586
H9KVD4 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 321 aa
36.5 kDa 		No 0
MECOM-016
ENSP00000394302
ENST00000433243
A0A0C3SFZ7 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 1052 aa
118.4 kDa 		No 0
MECOM-017
ENSP00000420466
ENST00000460814
E7EUL6 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016235 [aggresome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
Show all
 1003 aa
113 kDa 		No 0
MECOM-018
ENSP00000419995
ENST00000468789
Q03112 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016235 [aggresome]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043069 [negative regulation of programmed cell death]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046329 [negative regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0071425 [hematopoietic stem cell proliferation]
Show all
 1051 aa
118.3 kDa 		No 0
MECOM-019
ENSP00000420048
ENST00000472280
A0A0C3SFZ7 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 1052 aa
118.4 kDa 		No 0
MECOM-020
ENSP00000419770
ENST00000464456
Q03112 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016235 [aggresome]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043069 [negative regulation of programmed cell death]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046329 [negative regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0071425 [hematopoietic stem cell proliferation]
Show all
 1042 aa
117.1 kDa 		No 0
MECOM-201
ENSP00000264674
ENST00000264674
Q03112 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0001701 [in utero embryonic development]
GO:0001780 [neutrophil homeostasis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0009617 [response to bacterium]
GO:0009791 [post-embryonic development]
GO:0016235 [aggresome]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030900 [forebrain development]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0042127 [regulation of cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0043069 [negative regulation of programmed cell death]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046329 [negative regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0060039 [pericardium development]
GO:0071425 [hematopoietic stem cell proliferation]
GO:0072001 [renal system development]
GO:0090336 [positive regulation of brown fat cell differentiation]
GO:0098727 [maintenance of cell number]
Show all
 1116 aa
125.8 kDa 		No 0
MECOM-202
ENSP00000486104
ENST00000628990
Q03112 [Direct mapping]
MDS1 and EVI1 complex locus protein EVI1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0016235 [aggresome]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043069 [negative regulation of programmed cell death]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046329 [negative regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0051726 [regulation of cell cycle]
GO:0071425 [hematopoietic stem cell proliferation]
Show all
 1051 aa
118.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.