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SEH1L

CANCER ATLAS

Gene description

 SEH1-like nucleoporin

Protein class

 Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039964

GENE INFORMATION

Gene name

 SEH1L (HGNC Symbol)

Synonyms

 SEC13L, Seh1, SEH1A, SEH1B

Description

 SEH1-like nucleoporin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 12947133 - 12987536

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085415 (version 83.38)

Entrez gene

 81929

UniProt

 Q96EE3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96EE3

Antibodypedia

 SEH1L antibodies

PROTEIN BROWSER
SEH1L-001
SEH1L-002
SEH1L-005
SEH1L-006
SEH1L-007
SEH1L-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEH1L-001
ENSP00000262124
ENST00000262124
Q96EE3 [Direct mapping]
Nucleoporin SEH1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0032008 [positive regulation of TOR signaling]
GO:0034198 [cellular response to amino acid starvation]
GO:0034605 [cellular response to heat]
GO:0034629 [cellular protein complex localization]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051028 [mRNA transport]
GO:0051301 [cell division]
GO:0051315 [attachment of mitotic spindle microtubules to kinetochore]
GO:0055085 [transmembrane transport]
GO:0061700 [GATOR2 complex]
GO:1900034 [regulation of cellular response to heat]
Show all
 360 aa
39.6 kDa 		No 0
SEH1L-002
ENSP00000382779
ENST00000399892
Q96EE3 [Direct mapping]
Nucleoporin SEH1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0002534 [cytokine production involved in inflammatory response]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0032008 [positive regulation of TOR signaling]
GO:0034198 [cellular response to amino acid starvation]
GO:0034605 [cellular response to heat]
GO:0034629 [cellular protein complex localization]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051028 [mRNA transport]
GO:0051301 [cell division]
GO:0051315 [attachment of mitotic spindle microtubules to kinetochore]
GO:0055085 [transmembrane transport]
GO:0061700 [GATOR2 complex]
GO:1900034 [regulation of cellular response to heat]
Show all
 421 aa
46.6 kDa 		No 0
SEH1L-005
ENSP00000467605
ENST00000592170
K7EPZ5 [Direct mapping]
Nucleoporin SEH1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 77 aa
8.7 kDa 		No 0
SEH1L-006
ENSP00000467276
ENST00000589446
K7EP88 [Direct mapping]
Nucleoporin SEH1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 189 aa
21 kDa 		No 0
SEH1L-007
ENSP00000466959
ENST00000585730
K7ENI5 [Direct mapping]
Nucleoporin SEH1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 158 aa
17.6 kDa 		No 0
SEH1L-008
ENSP00000466234
ENST00000587761
K7ELV2 [Direct mapping]
Nucleoporin SEH1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 263 aa
29.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.