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Weak to moderate cytoplasmic or nuclear membranous positivity was observed in tumor cells in urothelial, basal cell and squamous cell carcinomas. All other cancer types were essentially negative.
Weak to moderate cytoplasmic and nuclear positivity was displayed in a subset of tumor cells in a few cancers including glioma, renal and thyroid cancer.
Aldo-keto reductase family 1, member B1 (aldose reductase) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
P15121 [Direct mapping] Aldose reductase A0A024R7A8 [Target identity:100%; Query identity:100%] Aldo-keto reductase family 1, member B1 (Aldose reductase), isoform CRA_a
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Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)