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Subsets of tumor cells in a few endometrial cancers and one malignant carcinoid displayed moderate cytoplasmic staining. A single case of adenocarcinoma of cervix showed strong positivity in a fraction of tumor cells. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
WNT11
Synonyms
Description
Wingless-type MMTV integration site family, member 11 (HGNC Symbol)
Entrez gene summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]