Cell atlas - MGST2 - The Human Protein Atlas

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MGST2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MGST2
Gene description	Microsomal glutathione S-transferase 2
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA010707
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA010707	A-431	No staining
	HPA010707	U-2 OS	No staining
	HPA010707	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	MGST2 (HGNC Symbol)
Synonyms	MGST-II
Description	Microsomal glutathione S-transferase 2 (HGNC Symbol)
Entrez gene summary	The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
Chromosome	4
Cytoband	q31.1
Chromosome location (bp)	139665768 - 139740745
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085871 (version 83.38)
Entrez gene	4258
UniProt	Q99735 (UniProt - Evidence at protein level)
neXtProt	NX_Q99735
Antibodypedia	MGST2 antibodies

PROTEIN BROWSER

MGST2-001	MGST2-006	MGST2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGST2-001 ENSP00000265498 ENST00000265498	Q99735 [Direct mapping] Microsomal glutathione S-transferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004464 [leukotriene-C4 synthase activity] GO:0004602 [glutathione peroxidase activity] GO:0005635 [nuclear envelope] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006691 [leukotriene metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008047 [enzyme activator activity] GO:0016021 [integral component of membrane] GO:0019370 [leukotriene biosynthetic process] GO:0043085 [positive regulation of catalytic activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1901687 [glutathione derivative biosynthetic process] Show all	147 aa 16.6 kDa	Yes	2
MGST2-006 ENSP00000424278 ENST00000506797	Q99735 [Direct mapping] Microsomal glutathione S-transferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004464 [leukotriene-C4 synthase activity] GO:0004602 [glutathione peroxidase activity] GO:0005635 [nuclear envelope] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006750 [glutathione biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008047 [enzyme activator activity] GO:0016021 [integral component of membrane] GO:0019370 [leukotriene biosynthetic process] GO:0043085 [positive regulation of catalytic activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1901687 [glutathione derivative biosynthetic process] Show all	77 aa 8.4 kDa	Yes	0
MGST2-201 ENSP00000482639 ENST00000616265	Q99735 [Direct mapping] Microsomal glutathione S-transferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004464 [leukotriene-C4 synthase activity] GO:0004602 [glutathione peroxidase activity] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006691 [leukotriene metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008047 [enzyme activator activity] GO:0010243 [response to organonitrogen compound] GO:0016021 [integral component of membrane] GO:0019370 [leukotriene biosynthetic process] GO:0032496 [response to lipopolysaccharide] GO:0043085 [positive regulation of catalytic activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:1901687 [glutathione derivative biosynthetic process] Show all	147 aa 16.6 kDa	Yes	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.